DIETHAZINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H22N2S.ClH
Molecular Weight	334.907
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN(CC)CCN1C2=CC=CC=C2SC3=C1C=CC=C3

InChI

InChIKey=LQZPJQKYAOYUJS-UHFFFAOYSA-N

InChI=1S/C18H22N2S.ClH/c1-3-19(4-2)13-14-20-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)20;/h5-12H,3-4,13-14H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H22N2S
Molecular Weight	298.446
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugfuture.com/chemdata/diethazine.html | Martindale, W. (1967) Extra Pharmacopoeia; Incorporating "Squires Companion", page 162, retrieved from: https://books.google.ru/books?id=xH-4AAAAIAAJ | Lemke, T.L., Williams, D.A. (2008) Foye's Principles of Medicinal Chemistry, page 606, retrieved from: https://books.google.ru/books?id=R0W1ErpsQpkC | (1973) Acta Physiologica Polonica, page 885, retrieved from: https://books.google.ru/books?id=9O9JAQAAIAAJ

Diethazine is the antimuscarinic agent. It has actions similar to those of ethopropazine but it is more toxic. Diethazine is used for the palliative treatment of the parkinsonian syndrome. It is more useful in the treatment of Parkinson’s disease than in allergies. Blockade of single contractions observed in these experiments after administration of diethazine was independent of the frequency of stimulation of the nerve. This suggests that the drug acts directly on the postsynaptic receptor in the endplate.

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:18:26 GMT 2023` Edited by `admin` on `Fri Dec 15 16:18:26 GMT 2023`
Record UNII	S88072126Q
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DIETHAZINE HYDROCHLORIDE

Common Name

English

RP 2987

Code

English

10-(2-DIETHYLAMINOETHYL)PHENOTHIAZINE HYDROCHLORIDE

Systematic Name

English

RP-2987

Code

English

DIETHAZINE HYDROCHLORIDE [MART.]

Common Name

English

DIETHAZINE HYDROCHLORIDE [MI]

Common Name

English

Diethazine hydrochloride [WHO-DD]

Common Name

English

DIETHAZINE HCL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578