Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C31H45NO5 |
| Molecular Weight | 511.6927 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@H](C)CN(CCC(=O)OC)[C@@]1([H])[C@@H](C)[C@@]3(CC[C@]4([H])C(C(=O)[C@@]5([H])[C@@]4([H])CC=C6C[C@@H](O)CC[C@]56C)=C3C)O2
InChI
InChIKey=MXDPCHQGAQFRMD-YSKIUEDOSA-N
InChI=1S/C31H45NO5/c1-17-14-24-28(32(16-17)13-10-25(34)36-5)19(3)31(37-24)12-9-22-23-7-6-20-15-21(33)8-11-30(20,4)27(23)29(35)26(22)18(31)2/h6,17,19,21-24,27-28,33H,7-16H2,1-5H3/t17-,19+,21-,22-,23-,24+,27+,28-,30-,31-/m0/s1
DescriptionCurator's Comment: description was created based on several sources, including:
https://en.wikipedia.org/wiki/Jervine | https://www.google.com/patents/US20150259313
Curator's Comment: description was created based on several sources, including:
https://en.wikipedia.org/wiki/Jervine | https://www.google.com/patents/US20150259313
Jervine (11-Ketocyclopamine) is a naturally occuring steroidal alkaloid is derived from the Veratrum plant species. Jervine is a teratogen implicated in birth defects when consumed by animals during a certain period of their gestation. Over the Hedgehog signaling pathway Jervine effectively inhibit the tumor growth using three human tumor xenograft models including lung cancer, pancreatic cancer and basal cell carcinoma. Jervine has the potential to advance to a treatment for different tumors.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development. | 2004 Dec 15 |
|
| Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. | 2004 May 19 |
|
| Critical time window of hedgehog-dependent angiogenesis in murine yolk sac. | 2006 Mar |
|
| Factors that regulate embryonic gustatory development. | 2007 Sep 18 |
|
| Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. | 2010 Jun |
|
| Hedgehog signaling is required at multiple stages of zebrafish tooth development. | 2010 Nov 30 |
Patents
Sample Use Guides
Oral: 40 or 60 or 80 mg/kg once every day (during 21 days).
Intravenous: 20 or 40 or 80 mg/kg once every day (during 21 days).
Route of Administration:
Other
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
132943-48-7
Created by
admin on Sat Dec 16 08:47:06 GMT 2023 , Edited by admin on Sat Dec 16 08:47:06 GMT 2023
|
PRIMARY | |||
|
14804161
Created by
admin on Sat Dec 16 08:47:06 GMT 2023 , Edited by admin on Sat Dec 16 08:47:06 GMT 2023
|
PRIMARY | |||
|
28779ZEX29
Created by
admin on Sat Dec 16 08:47:06 GMT 2023 , Edited by admin on Sat Dec 16 08:47:06 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
