HALOPREDONE ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H29BrF2O7
Molecular Weight	559.394
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)OCC(=O)[C@]1(CC[C@H]2[C@@H]3C[C@@H](F)C4=CC(=O)C(Br)=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)OC(C)=O

InChI

InChIKey=YCISZOVUHXIOFY-HKXOFBAYSA-N

InChI=1S/C25H29BrF2O7/c1-12(29)34-11-21(33)24(35-13(2)30)6-5-14-15-7-18(27)16-8-19(31)17(26)9-23(16,4)25(15,28)20(32)10-22(14,24)3/h8-9,14-15,18,20,32H,5-7,10-11H2,1-4H3/t14-,15-,18+,20-,22-,23-,24-,25-/m0/s1

HIDE SMILES / InChI

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3957156
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/341904

Halopredone (THS-201; (17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione; halopredone acetate; Topicon) is a highly topical corticosteroid. When it is used for intraarticular injections, the effects last longer than any other steroids which have been used, and it has less general effects. Halopredone acetate is used for arthritis and osteoarthritis (OA) patients. For RA patients, mean dose for a wrist is 12.5 mg and that for a knee is 25 mg. About 90% cases showed effectiveness and in about 45% cases the duration of effect is longer than 4 weeks. More than half cases of OA showed also improvements. It also possesses positive anti-inflammatory properties in dermatologic patients.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Arthritis 87 Sources: http://www.ncbi.nlm.nih.gov/pubmed/3718077	Primary		Preclinical	Unknown Approved Use Unknown
Dermatoses 23 Sources: http://www.ncbi.nlm.nih.gov/pubmed/341904	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Clinical study of the relationship between dose and response to halopredone acetate in dermatoses.	1977	341904

Patents

Sample Use Guides

In Vivo Use Guide

for rats: locally: 80 micrograms/pellet s.c.: 100 mg/kg

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

HALOPREDONE ACETATE

Official Name

English

HALOART

Preferred Name

English

Halopredone acetate [WHO-DD]

Common Name

English

TOPICON

Brand Name

English

HALOPREDONE ACETATE [JAN]

Common Name

English

HALOPREDONE ACETATE [MI]

Common Name

English

HALOPREDONE ACETATE [USAN]

Common Name

English

THS-201

Code

English

PREGNA-1,4-DIENE-3,20-DIONE, 17,21-BIS(ACETYLOXY)-2-BROMO-6,9-DIFLUORO-11-HYDROXY-, (6.BETA.,11.BETA.)-

Common Name

English

THS 201

Code

English

Code System Code Type Description

FDA UNII

24NUL39JY1