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Details

Stereochemistry ACHIRAL
Molecular Formula C26H28ClNO.C6H8O7
Molecular Weight 598.083
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of TOREMIFENE CITRATE

SMILES

OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOC1=CC=C(C=C1)C(=C(\CCCl)C2=CC=CC=C2)\C3=CC=CC=C3

InChI

InChIKey=IWEQQRMGNVVKQW-OQKDUQJOSA-N
InChI=1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020497s006lbl.pdf

Toremifene is an antineoplastic hormonal agent primarily used in the treatment of advanced breast cancer. Toremifene is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Toremifene inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, Toremifene appears to exert its antitumor effects by binding the estrogen receptors. In cytosols derived from human breast adenocarcinomas, Toremifene competes with estradiol for estrogen receptor protein. Toremifene is a nonsteroidal triphenylethylene derivative. Toremifene binds to estrogen receptors and may exert estrogenic, antiestrogenic, or both activities, depending upon the duration of treatment, animal species, gender, target organ, or endpoint selected. The antitumor effect of toremifene in breast cancer is believed to be mainly due to its antiestrogenic effects, in other words, its ability to compete with estrogen for binding sites in the cancer, blocking the growth-stimulating effects of estrogen in the tumor. Toremifene may also inhibit tumor growth through other mechanisms, such as induction of apoptosis, regulation of oncogene expression, and growth factors. Toremifene is used for the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer. Toremifene is marketed in the United States under the brand name Fareston.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
FARESTON

Approved Use

FARESTON® is an estrogen agonist/antagonist indicated for the treatment of metastatic breast cancer in postmenopausal women with estrogen-receptor positive or unknown tumors.

Launch Date

1997
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
414 ng/mL
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOREMIFENE blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
722 ng/mL
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOREMIFENE blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
28.4 μg × h/mL
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOREMIFENE blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
34.1 μg × h/mL
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOREMIFENE blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
6.2 day
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOREMIFENE blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
99 h
120 mg single, oral
dose: 120 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOREMIFENE blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
400 mg/m2 1 times / day steady, oral
MTD
Dose: 400 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 400 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 5
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 5
Sources: Page: 175
DLT: Nausea and vomiting, Dizziness...
Other AEs: Sweating, Peripheral edema...
Dose limiting toxicities:
Nausea and vomiting (grade 1-4, 5 patients)
Dizziness (grade 1-4, 4 patients)
Other AEs:
Sweating (grade 1-4, 3 patients)
Peripheral edema (grade 1-4, 3 patients)
Vaginal discharge (grade 1-4, 0%)
Hot flushes (grade 1-4, 2 patients)
Sources: Page: 175
200 mg/m2 1 times / day steady, oral
Recommended
Dose: 200 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 8
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 8
Sources: Page: 175
Other AEs: Nausea and vomiting, Dizziness...
Other AEs:
Nausea and vomiting (grade 1-4, 7 patients)
Dizziness (grade 1-4, 2 patients)
Sweating (grade 1-4, 2 patients)
Peripheral edema (grade 1-4, 2 patients)
Vaginal discharge (grade 1-4, 2 patients)
Hot flushes (grade 1-4, 1 patient)
Sources: Page: 175
300 mg/m2 1 times / day steady, oral
Recommended
Dose: 300 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 300 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 6
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 6
Sources: Page: 175
Other AEs: Nausea and vomiting, Dizziness...
Other AEs:
Nausea and vomiting (grade 1-4, 6 patients)
Dizziness (grade 1-4, 4 patients)
Sweating (grade 1-4, 3 patients)
Peripheral edema (grade 1-4, 4 patients)
Vaginal discharge (grade 1-4, 3 patients)
Hot flushes (grade 1-4, 4 patients)
Sources: Page: 175
AEs

AEs

AESignificanceDosePopulation
Vaginal discharge grade 1-4, 0%
400 mg/m2 1 times / day steady, oral
MTD
Dose: 400 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 400 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 5
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 5
Sources: Page: 175
Hot flushes grade 1-4, 2 patients
400 mg/m2 1 times / day steady, oral
MTD
Dose: 400 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 400 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 5
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 5
Sources: Page: 175
Peripheral edema grade 1-4, 3 patients
400 mg/m2 1 times / day steady, oral
MTD
Dose: 400 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 400 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 5
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 5
Sources: Page: 175
Sweating grade 1-4, 3 patients
400 mg/m2 1 times / day steady, oral
MTD
Dose: 400 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 400 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 5
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 5
Sources: Page: 175
Dizziness grade 1-4, 4 patients
DLT
400 mg/m2 1 times / day steady, oral
MTD
Dose: 400 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 400 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 5
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 5
Sources: Page: 175
Nausea and vomiting grade 1-4, 5 patients
DLT
400 mg/m2 1 times / day steady, oral
MTD
Dose: 400 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 400 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 5
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 5
Sources: Page: 175
Hot flushes grade 1-4, 1 patient
200 mg/m2 1 times / day steady, oral
Recommended
Dose: 200 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 8
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 8
Sources: Page: 175
Dizziness grade 1-4, 2 patients
200 mg/m2 1 times / day steady, oral
Recommended
Dose: 200 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 8
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 8
Sources: Page: 175
Peripheral edema grade 1-4, 2 patients
200 mg/m2 1 times / day steady, oral
Recommended
Dose: 200 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 8
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 8
Sources: Page: 175
Sweating grade 1-4, 2 patients
200 mg/m2 1 times / day steady, oral
Recommended
Dose: 200 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 8
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 8
Sources: Page: 175
Vaginal discharge grade 1-4, 2 patients
200 mg/m2 1 times / day steady, oral
Recommended
Dose: 200 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 8
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 8
Sources: Page: 175
Nausea and vomiting grade 1-4, 7 patients
200 mg/m2 1 times / day steady, oral
Recommended
Dose: 200 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 8
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 8
Sources: Page: 175
Sweating grade 1-4, 3 patients
300 mg/m2 1 times / day steady, oral
Recommended
Dose: 300 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 300 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 6
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 6
Sources: Page: 175
Vaginal discharge grade 1-4, 3 patients
300 mg/m2 1 times / day steady, oral
Recommended
Dose: 300 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 300 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 6
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 6
Sources: Page: 175
Dizziness grade 1-4, 4 patients
300 mg/m2 1 times / day steady, oral
Recommended
Dose: 300 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 300 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 6
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 6
Sources: Page: 175
Hot flushes grade 1-4, 4 patients
300 mg/m2 1 times / day steady, oral
Recommended
Dose: 300 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 300 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 6
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 6
Sources: Page: 175
Peripheral edema grade 1-4, 4 patients
300 mg/m2 1 times / day steady, oral
Recommended
Dose: 300 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 300 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 6
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 6
Sources: Page: 175
Nausea and vomiting grade 1-4, 6 patients
300 mg/m2 1 times / day steady, oral
Recommended
Dose: 300 mg/m2, 1 times / day
Route: oral
Route: steady
Dose: 300 mg/m2, 1 times / day
Sources: Page: 175
unhealthy, 38 - 79 years
n = 6
Health Status: unhealthy
Condition: metastatic breast cancer
Age Group: 38 - 79 years
Sex: F
Population Size: 6
Sources: Page: 175
PubMed

PubMed

TitleDatePubMed
Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts.
1995 Mar
Comparison of the effects of tamoxifen and toremifene on liver and kidney tumor promotion in female rats.
1995 Nov
Comparison of the effects of tamoxifen and toremifene on rat hepatocarcinogenesis.
2000 Jul
Effect of anti-estrogens on the androgen receptor activity and cell proliferation in prostate cancer cells.
2004 Dec
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
In silico prediction of pregnane X receptor activators by machine learning approaches.
2007 Jan
Patents

Sample Use Guides

60 mg once daily, orally
Route of Administration: Oral
In Vitro Use Guide
Treatment of the human breast cancer cell line MCF-7 with 7.5 uM toremifene for 3 days caused approximately 60% of the cells to exhibit morphologic characteristics typical of cells undergoing apoptosis.
Name Type Language
TOREMIFENE CITRATE
JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN  
Official Name English
Toremifene citrate [WHO-DD]
Common Name English
2-[P-[(Z)-4-Chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethylethylamine citrate (1:1)
Common Name English
TOREMIFENE CITRATE [ORANGE BOOK]
Common Name English
FC-1157A
Code English
TOREMIFENE CITRATE [MART.]
Common Name English
ETHANAMINE, 2-(4-(4-CHLORO-1,2-DIPHENYL-1-BUTENYL)PHENOXY)-N,N-DIMETHYL-, (Z)-, 2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE (1:1)
Common Name English
FARESTON
Brand Name English
TOREMIFENE CITRATE [VANDF]
Common Name English
TOREMIFENE CITRATE [MI]
Common Name English
TOREMIFENE CITRATE [USAN]
Common Name English
TOREMIFENE CITRATE [JAN]
Common Name English
NSC-613680
Code English
Classification Tree Code System Code
NCI_THESAURUS C1821
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
Code System Code Type Description
DAILYMED
2498Y783QT
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
NCI_THESAURUS
C1756
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
USAN
Z-51
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
NSC
613680
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
FDA UNII
2498Y783QT
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
RXCUI
49953
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID2021367
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
DRUG BANK
DBSALT001447
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PRIMARY
MERCK INDEX
m10979
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY Merck Index
SMS_ID
100000085256
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PRIMARY
PUBCHEM
3005572
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
EVMPD
SUB04923MIG
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
ChEMBL
CHEMBL1655
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY
CAS
89778-27-8
Created by admin on Fri Dec 15 15:09:55 GMT 2023 , Edited by admin on Fri Dec 15 15:09:55 GMT 2023
PRIMARY