Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C45H53NO14.2H2O |
| Molecular Weight | 867.9312 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)[C@H]4[C@]5(C[C@H]5C[C@H]6OC[C@@]46OC(C)=O)C1=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C7=CC=CC=C7
InChI
InChIKey=SEFGUGYLLVNFIJ-QDRLFVHASA-N
InChI=1S/C45H53NO14.2H2O/c1-23-29(57-39(52)33(49)32(26-15-11-9-12-16-26)46-40(53)60-41(4,5)6)21-45(54)37(58-38(51)27-17-13-10-14-18-27)35-43(36(50)34(56-24(2)47)31(23)42(45,7)8)20-28(43)19-30-44(35,22-55-30)59-25(3)48;;/h9-18,28-30,32-35,37,49,54H,19-22H2,1-8H3,(H,46,53);2*1H2/t28-,29+,30-,32+,33-,34-,35+,37+,43-,44+,45-;;/m1../s1
LAROTAXEL is a taxoid with potential antineoplastic activity. It prevents microtubule depolymerization, thereby inhibiting cell proliferation. It displays a broad spectrum of antitumor activity in vitro and in vivo, including activity against P-glycoprotein expressing tumors. LAROTAXEL was in phase III clinical trials for the treatment of breast cancer, pancreatic cancer, and bladder cancer. However, its development was discontinued.
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Larotaxel: broadening the road with new taxanes. | 2009-08 |
|
| Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy. | 2008-07 |
|
| Preclinical evaluation of new taxoids. | 2001-09 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
300000052828
Created by
admin on Mon Mar 31 18:06:21 GMT 2025 , Edited by admin on Mon Mar 31 18:06:21 GMT 2025
|
PRIMARY | |||
|
6918259
Created by
admin on Mon Mar 31 18:06:21 GMT 2025 , Edited by admin on Mon Mar 31 18:06:21 GMT 2025
|
PRIMARY | |||
|
23K148PYZO
Created by
admin on Mon Mar 31 18:06:21 GMT 2025 , Edited by admin on Mon Mar 31 18:06:21 GMT 2025
|
PRIMARY | |||
|
DTXSID80172850
Created by
admin on Mon Mar 31 18:06:21 GMT 2025 , Edited by admin on Mon Mar 31 18:06:21 GMT 2025
|
PRIMARY | |||
|
192573-38-9
Created by
admin on Mon Mar 31 18:06:21 GMT 2025 , Edited by admin on Mon Mar 31 18:06:21 GMT 2025
|
PRIMARY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
