Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C45H53NO14.2H2O |
Molecular Weight | 867.9312 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 11 / 11 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[H][C@@]12C[C@@]13C(=O)[C@H](OC(C)=O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C5=CC=CC=C5)[C@]3([H])[C@@]6(CO[C@]6([H])C2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C7=CC=CC=C7
InChI
InChIKey=SEFGUGYLLVNFIJ-QDRLFVHASA-N
InChI=1S/C45H53NO14.2H2O/c1-23-29(57-39(52)33(49)32(26-15-11-9-12-16-26)46-40(53)60-41(4,5)6)21-45(54)37(58-38(51)27-17-13-10-14-18-27)35-43(36(50)34(56-24(2)47)31(23)42(45,7)8)20-28(43)19-30-44(35,22-55-30)59-25(3)48;;/h9-18,28-30,32-35,37,49,54H,19-22H2,1-8H3,(H,46,53);2*1H2/t28-,29+,30-,32+,33-,34-,35+,37+,43-,44+,45-;;/m1../s1
Molecular Formula | C45H53NO14 |
Molecular Weight | 831.9006 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 10 / 11 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
LAROTAXEL is a taxoid with potential antineoplastic activity. It prevents microtubule depolymerization, thereby inhibiting cell proliferation. It displays a broad spectrum of antitumor activity in vitro and in vivo, including activity against P-glycoprotein expressing tumors. LAROTAXEL was in phase III clinical trials for the treatment of breast cancer, pancreatic cancer, and bladder cancer. However, its development was discontinued.
CNS Activity
Originator
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:42:45 UTC 2023
by
admin
on
Fri Dec 15 15:42:45 UTC 2023
|
Record UNII |
23K148PYZO
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
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Code | English |
Code System | Code | Type | Description | ||
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6918259
Created by
admin on Fri Dec 15 15:42:45 UTC 2023 , Edited by admin on Fri Dec 15 15:42:45 UTC 2023
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PRIMARY | |||
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23K148PYZO
Created by
admin on Fri Dec 15 15:42:45 UTC 2023 , Edited by admin on Fri Dec 15 15:42:45 UTC 2023
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DTXSID80172850
Created by
admin on Fri Dec 15 15:42:45 UTC 2023 , Edited by admin on Fri Dec 15 15:42:45 UTC 2023
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192573-38-9
Created by
admin on Fri Dec 15 15:42:45 UTC 2023 , Edited by admin on Fri Dec 15 15:42:45 UTC 2023
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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ANHYDROUS->SOLVATE |