Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C28H45NO5S |
| Molecular Weight | 507.726 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]3C)OC(=O)CS[C@@H]4CC[C@@H](N)C[C@H]4O
InChI
InChIKey=KPVIXBKIJXZQJX-CSOZIWFHSA-N
InChI=1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16?,17-,18+,20+,21+,22+,24-,25-,26+,27-,28-/m0/s1
LEFAMULIN is a pleuromutilin antibiotic under development for the treatment of community-acquired bacterial pneumonia, as well as acute bacterial skin and skin structure infections. It inhibits bacterial protein synthesis by binding to the peptidyl transferase center of the 50S ribosome, resulting in the cessation of bacterial growth.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Simultaneous assessment of the pharmacokinetics of a pleuromutilin, lefamulin, in plasma, soft tissues and pulmonary epithelial lining fluid. | 2016 Apr |
|
| In Vitro Activity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States. | 2016 Jul |
|
| Lefamulin: Review of a Promising Novel Pleuromutilin Antibiotic. | 2018 Sep |
Sample Use Guides
Lefamulin was evaluated against various Streptococcus pneumoniae serotypes that were collected from adults with lower respiratory tract infections. Lefamulin exhibited MIC50 and MIC90 values of 0.12 and 0.25 μg/ml, respectively, against the entire collection (n = 822). Similar results were obtained for lefamulin against each of the most common serotypes as well as against multidrug-resistant isolates and strains that are nonsusceptible to ceftriaxone or erythromycin.
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CHEMBL3291398
Created by
admin on Mon Oct 21 19:48:30 UTC 2019 , Edited by admin on Mon Oct 21 19:48:30 UTC 2019
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9849
Created by
admin on Mon Oct 21 19:48:30 UTC 2019 , Edited by admin on Mon Oct 21 19:48:30 UTC 2019
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25185057
Created by
admin on Mon Oct 21 19:48:30 UTC 2019 , Edited by admin on Mon Oct 21 19:48:30 UTC 2019
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1061337-51-6
Created by
admin on Mon Oct 21 19:48:30 UTC 2019 , Edited by admin on Mon Oct 21 19:48:30 UTC 2019
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
