TAZADOLENE SUCCINATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H21N.C4H6O4
Molecular Weight	345.4327
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CCC(O)=O.C1CN(C1)C2CCCC\C2=C/C3=CC=CC=C3

InChI

InChIKey=IEXXCIWKNWOEKZ-GVYCEHEKSA-N

InChI=1S/C16H21N.C4H6O4/c1-2-7-14(8-3-1)13-15-9-4-5-10-16(15)17-11-6-12-17;5-3(6)1-2-4(7)8/h1-3,7-8,13,16H,4-6,9-12H2;1-2H2,(H,5,6)(H,7,8)/b15-13+;

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2855569

Tazadolene was developed as a novel non-opioid analgesic with antidepressant properties. Experiments on rodents have revealed that unique analgesia properties of tazadolene was due to the ability of this compound to activate both serotonergic and alpha 2 adrenergic antinociceptive systems. Information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Reversed-phase high-performance liquid chromatographic assay for the determination of potency and impurities in tazadolene succinate bulk drug and capsules.	1986 Feb 26	3700522
Evidence for the combined involvement of serotonergic and alpha 2 adrenergic mechanisms in the analgesic activity of tazadolene succinate.	1987 Dec	2855569

Patents

Name

Type

Language

TAZADOLENE SUCCINATE

Official Name

English

BUTANEDIOIC ACID, COMPD. WITH 1-((2E)-2-(PHENYLMETHYLENE)CYCLOHEXYL)AZETIDINE (1:1)

Systematic Name

English

TAZADOLENE SUCCINATE [USAN]

Common Name

English

U-53,996H

Code

English

U-53996H

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C2198