Details
Stereochemistry | RACEMIC |
Molecular Formula | C16H26N2O4 |
Molecular Weight | 310.3886 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)NCCC1=CC=C(OCC(O)CNC(C)C)C=C1
InChI
InChIKey=UGENBJKPPGFFAT-UHFFFAOYSA-N
InChI=1S/C16H26N2O4/c1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3/h4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20)
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/28193 |
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28193 |
Pamatolol is a beta-Adrenergic receptor antagonist was studied as an Antiarrhythmic agent. The phase I clinical trial has shown that the drug was relatively cardioselective in man. Information about the further development of this drug is not available.
Approval Year
PubMed
Title | Date | PubMed |
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Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol. | 1979 |
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Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker. | 1979 Dec |
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Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles. | 1985 Mar |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/40725
Minor reductions in standing and exercise and isoproterenol-induced increases in heart rate were observed with the 10-mg oral dose and appeared maximal with the 400-600 mg dose.
Route of Administration:
Oral
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CHEMBL2110710
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59110-35-9
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SUB09596MIG
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4104
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20G2S6V53L
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Pamatolol
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C166527
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C017601
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100000082783
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43150
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)