PAMATOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H26N2O4
Molecular Weight	310.3886
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)NCCC1=CC=C(OCC(O)CNC(C)C)C=C1

InChI

InChIKey=UGENBJKPPGFFAT-UHFFFAOYSA-N

InChI=1S/C16H26N2O4/c1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3/h4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28193 |

Pamatolol is a beta-Adrenergic receptor antagonist was studied as an Antiarrhythmic agent. The phase I clinical trial has shown that the drug was relatively cardioselective in man. Information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol.	1979	38629
Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker.	1979 Dec	40725
Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.	1985 Mar	2582279

Sample Use Guides

In Vivo Use Guide

Minor reductions in standing and exercise and isoproterenol-induced increases in heart rate were observed with the 10-mg oral dose and appeared maximal with the 400-600 mg dose.

Route of Administration: Oral

Name

Type

Language

PAMATOLOL

Official Name

English

CARBAMIC ACID, (2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-, METHYL ESTER, (±)-

Common Name

English

pamatolol [INN]

Common Name

English

METHYL (±)-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)CARBAMATE

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL2110710