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Details

Stereochemistry RACEMIC
Molecular Formula C16H26N2O4
Molecular Weight 310.3886
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PAMATOLOL

SMILES

COC(=O)NCCC1=CC=C(OCC(O)CNC(C)C)C=C1

InChI

InChIKey=UGENBJKPPGFFAT-UHFFFAOYSA-N
InChI=1S/C16H26N2O4/c1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3/h4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20)

HIDE SMILES / InChI
Pamatolol is a beta-Adrenergic receptor antagonist was studied as an Antiarrhythmic agent. The phase I clinical trial has shown that the drug was relatively cardioselective in man. Information about the further development of this drug is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol.
1979
Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker.
1979 Dec
Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.
1985 Mar

Sample Use Guides

In Vivo Use Guide
Minor reductions in standing and exercise and isoproterenol-induced increases in heart rate were observed with the 10-mg oral dose and appeared maximal with the 400-600 mg dose.
Route of Administration: Oral
Name Type Language
PAMATOLOL
INN  
INN  
Official Name English
CARBAMIC ACID, (2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-, METHYL ESTER, (±)-
Common Name English
pamatolol [INN]
Common Name English
METHYL (±)-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)CARBAMATE
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL2110710
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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CAS
59110-35-9
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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EVMPD
SUB09596MIG
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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INN
4104
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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FDA UNII
20G2S6V53L
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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WIKIPEDIA
Pamatolol
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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NCI_THESAURUS
C166527
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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MESH
C017601
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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SMS_ID
100000082783
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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PUBCHEM
43150
Created by admin on Fri Dec 15 16:49:22 GMT 2023 , Edited by admin on Fri Dec 15 16:49:22 GMT 2023
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