PAMATOLOL SULFATE

Details

Stereochemistry	RACEMIC
Molecular Formula	2C16H26N2O4.H2O4S
Molecular Weight	718.856
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(O)(=O)=O.COC(=O)NCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COC(=O)NCCC2=CC=C(OCC(O)CNC(C)C)C=C2

InChI

InChIKey=OUXGIOLQOYAZLS-UHFFFAOYSA-N

InChI=1S/2C16H26N2O4.H2O4S/c2*1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3;1-5(2,3)4/h2*4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20);(H2,1,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C16H26N2O4
Molecular Weight	310.3886
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28193 |

Pamatolol is a beta-Adrenergic receptor antagonist was studied as an Antiarrhythmic agent. The phase I clinical trial has shown that the drug was relatively cardioselective in man. Information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol.	1979	38629
Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker.	1979 Dec	40725
Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.	1985 Mar	2582279

Sample Use Guides

In Vivo Use Guide

Minor reductions in standing and exercise and isoproterenol-induced increases in heart rate were observed with the 10-mg oral dose and appeared maximal with the 400-600 mg dose.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:27:15 GMT 2023` Edited by `admin` on `Fri Dec 15 17:27:15 GMT 2023`
Record UNII	1RT2DU4P6T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PAMATOLOL SULFATE

Official Name

English

METHYL (±)-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)CARBAMATE SULPHATE (SALT) (2:1)

Common Name

English

CARBAMIC ACID, (2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-, METHYL ESTER, (±)-, SULFATE (SALT) (2:1)

Common Name

English

METHYL (±)-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)CARBAMATE SULFATE (SALT) (2:1)

Common Name

English

PAMATOLOL SULFATE [USAN]

Common Name

English

PAMATOLOL SULPHATE

Common Name

English

H 104/08

Code

English

CARBAMIC ACID, (2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-, METHYL ESTER, (±)-, SULPHATE (SALT) (2:1)

Common Name

English

H-104/08

Code

English

Code System Code Type Description

FDA UNII

1RT2DU4P6T