Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H20Cl2N2O |
| Molecular Weight | 327.249 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CO\N=C\[C@H]1[C@H]2CC[C@@H](C[C@@H]1C3=CC=C(Cl)C(Cl)=C3)N2C
InChI
InChIKey=NRLIFEGHTNUYFL-QJDHNRDASA-N
InChI=1S/C16H20Cl2N2O/c1-20-11-4-6-16(20)13(9-19-21-2)12(8-11)10-3-5-14(17)15(18)7-10/h3,5,7,9,11-13,16H,4,6,8H2,1-2H3/b19-9+/t11-,12+,13+,16+/m0/s1
NeuroSearch was developing brasofensine (or NS 2214), an oral dopamine reuptake inhibitor for the treatment of Parkinson's disease. Brasofensine successfully passed phase II clinical trial in patients with Parkinson's disease, The drug was safe and well tolerated. However, NeuroSearch discontinued the development of the drug because of the cis-anti isomerization of the 2α-methyloxime group of brasofensine in favor of NS 2230.
Originator
Approval Year
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C38149
Created by
admin on Sat Dec 16 17:20:47 GMT 2023 , Edited by admin on Sat Dec 16 17:20:47 GMT 2023
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DTXSID00905102
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SUB05881MIG
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CHEMBL2104184
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100000088658
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C415103
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171655-91-7
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9614919
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C76391
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7530
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BRASOFENSINE
Created by
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DB04857
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1YP2S94RVH
Created by
admin on Sat Dec 16 17:20:47 GMT 2023 , Edited by admin on Sat Dec 16 17:20:47 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
