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Description
Curator's Comment:: The description was created based on several sources, including https://www.drugbank.ca/drugs/DB00030

Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Insulin lowers blood glucose levels by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis in adipocytes, inhibits proteolysis, and enhances protein synthesis. Human insulin begins to exert its effects within 30 minutes of subcutaneous administration, while peak levels occur 3-4 hours after administration. Due to its quick onset of action, human insulin is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals. Bolus insulin is often combined with once daily, long-acting "basal insulin" to provide low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
HUMULIN N

Approved Use

HUMULIN N is an intermediate-acting human insulin indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus
Name Type Language
INSULIN HUMAN
EMA EPAR   INN   USAN   USP   WHO-DD  
USAN   INN  
Official Name English
INSULIN HUMAN SEMISYNTHETIC [WHO-DD]
Common Name English
HUMULIN
Brand Name English
REGULAR INSULIN, HUMAN
Common Name English
HUMULIN BR
Brand Name English
HUMAN INSULIN
Common Name English
RPROT P01308 (INS_HUMAN) INSULIN (HGI519)
Common Name English
INSULIN RECONBINANET HUMAN
Common Name English
INSULIN,REGULAR,HUMAN BUFFERED [VANDF]
Common Name English
INSULIN INJECTION HUMAN BIOSYNTHETIC
Common Name English
INSULIN HUMAN [EMA EPAR]
Common Name English
INSULIN, HUMAN [EP MONOGRAPH]
Common Name English
INSULIN,ULTRALENTE,HUMAN
VANDF  
Common Name English
INSULIN RECOMBINANT HUMAN
Common Name English
INSULIN RECOMBINANT PURIFIED HUMAN
Common Name English
INSULIN HUMAN REGULAR
Common Name English
INSULIN HUMAN NPH
Common Name English
INSULIN (OX), 8A-L-THREONINE-10A-L-ISOLEUCINE-30B-L-THREONINE-
Common Name English
HIGH MOLECULAR WEIGHT INSULIN HUMAN [USP-RS]
Common Name English
INSULIN,REGULAR,HUMAN/RDNA
Common Name English
INSULIN,REGULAR,HUMAN BUFFERED
VANDF  
Common Name English
INSULIN, HUMAN
Common Name English
INSULIN (HUMAN)
Common Name English
INSULIN HUMAN [USAN]
Common Name English
ACTRAPID
Brand Name English
INSULIN,LENTE,HUMAN/SEMISYNTHETIC
Common Name English
INSULIN,REGULAR,HUMAN/SEMISYNTHETIC
Common Name English
INSULIN HUMAN REGULAR (RDNA)
Common Name English
MYXREDLIN
Brand Name English
INSULIN,ULTRALENTE,HUMAN [VANDF]
Common Name English
INSULIN HUMAN [USP-RS]
Common Name English
CAPSULIN
Brand Name English
INSULIN,NPH,HUMAN/RDNA
Common Name English
INSULIN HUMAN, RDNA ORIGIN
Common Name English
INSULIN,NPH,HUMAN/SEMISYNTHETIC
Common Name English
AFREZZA
Brand Name English
INSULIN HUMAN [INN]
Common Name English
INSULIN HUMAN LENTE
Common Name English
HUMULIN R
Brand Name English
INSULIN SEMISYNTHETIC HUMAN
Common Name English
INSULIN HUMAN [USP MONOGRAPH]
Common Name English
INSULIN SEMI SYNTHETIC HUMAN
Common Name English
VIATAB
Brand Name English
INSULIN HUMAN RDNA
Common Name English
INSULIN RECOMBINANT HUMAN [ORANGE BOOK]
Common Name English
INSULIN,LENTE,HUMAN/RDNA
Common Name English
INSULIN,ULTRALENTE,HUMAN/RDNA
Common Name English
INSULIN HUMAN [WHO-DD]
Common Name English
HIGH MOLECULAR WEIGHT INSULIN HUMAN
USP-RS  
Common Name English
Classification Tree Code System Code
WHO-VATC QA10AE01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-VATC QA10AF01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
CFR 21 CFR 522.1160
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
NDF-RT N0000004931
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
FDA ORPHAN DRUG 469115
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-ATC A10AE01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-VATC QA10AB01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-ATC A10AF01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
NDF-RT N0000175944
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
EU-Orphan Drug EU/3/15/1532
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-ATC A10AB01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-VATC QA10AD01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
NCI_THESAURUS C581
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-ATC A10AD01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
NDF-RT N0000004931
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-ATC A10AC01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
NDF-RT N0000004931
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
WHO-VATC QA10AC01
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
Code System Code Type Description
ECHA (EC/EINECS)
234-279-7
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
RXCUI
631657
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
ALTERNATIVE
CAS
9004-10-8
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
GENERIC (FAMILY)
ChEMBL
CHEMBL1201631
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
NCI_THESAURUS
C65922
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
EVMPD
SUB128649
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
ALTERNATIVE
EVMPD
SUB08197MIG
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
EVMPD
SUB25169
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
LACTMED
Insulin
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
ChEMBL
CHEMBL2108500
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
EVMPD
SUB25235
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
FDA UNII
1Y17CTI5SR
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
EVMPD
SUB25234
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
EPA CompTox
11061-68-0
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
CAS
11061-68-0
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
ChEMBL
CHEMBL2108973
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
RXCUI
253182
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
IUPHAR
5012
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
INN
5186
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
ChEMBL
CHEMBL2108974
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
DRUG BANK
DB00030
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
MERCK INDEX
M6293
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY Merck Index
DRUG CENTRAL
5003
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
PUBCHEM
16129672
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY
USP_CATALOG
1342106
Created by admin on Fri Jun 25 20:56:44 UTC 2021 , Edited by admin on Fri Jun 25 20:56:44 UTC 2021
PRIMARY USP-RS