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Details

Stereochemistry ACHIRAL
Molecular Formula C22H27ClN2O.ClH
Molecular Weight 407.377
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LORCAINIDE HYDROCHLORIDE

SMILES

Cl.CC(C)N1CCC(CC1)N(C(=O)CC2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=FSFSWNBDCJVFGI-UHFFFAOYSA-N
InChI=1S/C22H27ClN2O.ClH/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18;/h3-11,17,21H,12-16H2,1-2H3;1H

HIDE SMILES / InChI

Description

Lorcainide is a class Ic antiarrhythmic medication. It was reported to be highly efficient for the treatment of ventricular arrhythmias, ventricular fibrillation, and tachycardia. The drug was used under the name Remivox. The mechanism of lorcainide action involves the blockage of sodium channels. Lorcainide was withdrawn from the market for a commercial reason, but later it was admitted that the use of the drug is associated with high risk of death.

CNS Activity

CNS Active
3,913

Originator

Cession-Fossion, A.|Monard, Y.|Dresse, A.
34

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
Sodium channel alpha subunit
76
Blocker
537

Conditions

ConditionModalityTargetsHighest PhaseProduct
Ventricular arrhythmia
50
 Primary
Withdrawn
Unknown
Ventricular tachycardia
11
 Primary
Withdrawn
Unknown
Supraventricular tachycardia
8
 Primary
Withdrawn
Unknown
Ventricular fibrillation
4
 Primary
Withdrawn
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Lorcainide is given orally at a dose 50-100 mg 2-3 times/day after a meal; the drug can be also administered as a slow intravenous injection at a dose of 1-2 mg for 5-10 min and the dose can be repeated every 8-12 h.
Route of Administration: Other
In Vitro Use Guide
Unknown
ACTIVE MOIETY
Structure of LORCAINIDE
NIH
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