Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H27ClN2O.ClH |
Molecular Weight | 407.377 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)N1CCC(CC1)N(C(=O)CC2=CC=CC=C2)C3=CC=C(Cl)C=C3
InChI
InChIKey=FSFSWNBDCJVFGI-UHFFFAOYSA-N
InChI=1S/C22H27ClN2O.ClH/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18;/h3-11,17,21H,12-16H2,1-2H3;1H
Lorcainide is a class Ic antiarrhythmic medication. It was reported to be highly efficient for the treatment of ventricular arrhythmias, ventricular fibrillation, and tachycardia. The drug was used under the name Remivox. The mechanism of lorcainide action involves the blockage of sodium channels. Lorcainide was withdrawn from the market for a commercial reason, but later it was admitted that the use of the drug is associated with high risk of death.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6734299
Curator's Comment: The drug has an effect on the CNS system.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2331043 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8358576 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseFor the stability of ventricular arrhythmias, ventricular tachycardia, ventricular fibrillation, ventricular contraction, supraventricular tachycardia and intractable ventricular tachycardia. |
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Primary | Unknown Approved UseFor the stability of ventricular arrhythmias, ventricular tachycardia, ventricular fibrillation, ventricular contraction, supraventricular tachycardia and intractable ventricular tachycardia. |
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Primary | Unknown Approved UseFor the stability of ventricular arrhythmias, ventricular tachycardia, ventricular fibrillation, ventricular contraction, supraventricular tachycardia and intractable ventricular tachycardia. |
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Primary | Unknown Approved UseFor the stability of ventricular arrhythmias, ventricular tachycardia, ventricular fibrillation, ventricular contraction, supraventricular tachycardia and intractable ventricular tachycardia. |
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C47793
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m6907
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310411
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100000086153
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C66034
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ACTIVE MOIETY
SUBSTANCE RECORD