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Details

Stereochemistry RACEMIC
Molecular Formula 2C16H26N2O4.H2O4S
Molecular Weight 718.856
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PAMATOLOL SULFATE

SMILES

OS(O)(=O)=O.COC(=O)NCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COC(=O)NCCC2=CC=C(OCC(O)CNC(C)C)C=C2

InChI

InChIKey=OUXGIOLQOYAZLS-UHFFFAOYSA-N
InChI=1S/2C16H26N2O4.H2O4S/c2*1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3;1-5(2,3)4/h2*4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20);(H2,1,2,3,4)

HIDE SMILES / InChI

Description

Pamatolol is a beta-Adrenergic receptor antagonist was studied as an Antiarrhythmic agent. The phase I clinical trial has shown that the drug was relatively cardioselective in man. Information about the further development of this drug is not available.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol.
1979
Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker.
1979 Dec
Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.
1985 Mar

Sample Use Guides

In Vivo Use Guide
Minor reductions in standing and exercise and isoproterenol-induced increases in heart rate were observed with the 10-mg oral dose and appeared maximal with the 400-600 mg dose.
Route of Administration: Oral
Name Type Language
PAMATOLOL SULFATE
USAN  
USAN  
Official Name English
METHYL (±)-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)CARBAMATE SULPHATE (SALT) (2:1)
Common Name English
CARBAMIC ACID, (2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-, METHYL ESTER, (±)-, SULFATE (SALT) (2:1)
Common Name English
METHYL (±)-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)CARBAMATE SULFATE (SALT) (2:1)
Common Name English
PAMATOLOL SULFATE [USAN]
Common Name English
PAMATOLOL SULPHATE
Common Name English
H 104/08
Code English
CARBAMIC ACID, (2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-, METHYL ESTER, (±)-, SULPHATE (SALT) (2:1)
Common Name English
H-104/08
Code English
Code System Code Type Description
FDA UNII
1RT2DU4P6T
Created by admin on Fri Dec 15 17:27:15 GMT 2023 , Edited by admin on Fri Dec 15 17:27:15 GMT 2023
PRIMARY
NCI_THESAURUS
C166513
Created by admin on Fri Dec 15 17:27:15 GMT 2023 , Edited by admin on Fri Dec 15 17:27:15 GMT 2023
PRIMARY
PUBCHEM
43149
Created by admin on Fri Dec 15 17:27:15 GMT 2023 , Edited by admin on Fri Dec 15 17:27:15 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110710
Created by admin on Fri Dec 15 17:27:15 GMT 2023 , Edited by admin on Fri Dec 15 17:27:15 GMT 2023
PRIMARY
EPA CompTox
DTXSID70975377
Created by admin on Fri Dec 15 17:27:15 GMT 2023 , Edited by admin on Fri Dec 15 17:27:15 GMT 2023
PRIMARY
CAS
59954-01-7
Created by admin on Fri Dec 15 17:27:15 GMT 2023 , Edited by admin on Fri Dec 15 17:27:15 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of PAMATOLOL
SUBSTANCE RECORD
Structure of PAMATOLOL SULFATE
NIH
NCATS
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