U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2C3H5GeO2.3O
Molecular Weight 339.42
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPAGERMANIUM

SMILES

[O--].[O--].[O--].OC(=O)CC[Ge+3].OC(=O)CC[Ge+3]

InChI

InChIKey=ZBANESJQZVORBE-UHFFFAOYSA-N
InChI=1S/2C3H5GeO2.3O/c2*4-2-1-3(5)6;;;/h2*1-2H2,(H,5,6);;;/q2*+3;3*-2

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: http://www.rad-ar.or.jp/siori/english/kekka_plain.cgi?n=1339 |https://www.ncbi.nlm.nih.gov/pubmed/12825127

Propagermanium, a newly introduced hydrophilic polymer of 3-oxygermanium propionic acid (3,3’-(1,3- dioxo-1,3-digermoxanediyl) bispropionic acid) has been reported to have antiinflammatory, antiviral and antineoplastic properties. In Japan propagermanium is approved for the treatment of HBe positive chronic hepatitis B. A postmarketing survey, however, revealed the occurrence of moderate to severe liver damage after the treatment in about 4% of patients. In most countries propagermanium falls under the regulations of dietary supplements. An import alert on germanium products was imposed by the U.S. FDA in 1988, because of possible injury to health. In Germany governmental institutions warned consumers of possibly fatal kidney damage.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SEROCION

Approved Use

It is approved for the treatment of HBe positive chronic hepatitis B.
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Effect of NK-421 (Bestatin) and Ge-132 on the cytotoxicity of spleen cells obtained from the tumor-bearing mice].
1982 Oct
Biological activities and antitumor mechanism of an immunopotentiating organogermanium compound, Ge-132 (review).
1987 Jul-Aug
Effect of germanium-132 on low-density lipoprotein oxidation and atherosclerosis in Kurosawa and Kusanagi hypercholesterolemic rabbits.
2001 Aug
Propagermanium: a nonspecific immune modulator for chronic hepatitis B.
2003
Patents

Sample Use Guides

30 mg per day (10 mg of the active ingredient at a time, 3 times daily, after meal)
Route of Administration: Oral
THP-1 cells were incubated with propagermanium at 37°C for 15 min in 5% CO2. The cells (5 x 10^6 cells/25 ul) were mixed with 125I-MCP-1 (227 pM, 25 ul) at 25°C for 45 min. Propagermanium at concentrations 0.1, 0.3 and 1mg/ml prevents MCP-1-induced chemotaxis of THP-1 cells and human PBMC.
Name Type Language
PROPAGERMANIUM
INCI   INN   MI   WHO-DD  
INN   INCI  
Official Name English
NSC-267004
Code English
REPAGERMANIUM [INCI]
Common Name English
Propagermanium [WHO-DD]
Common Name English
PROPAGERMANIUM [MI]
Common Name English
BIS(CARBOXYETHYL)GERMANIUM SESQUIOXIDE
Common Name English
repagermanium [INN]
Common Name English
propagermanium [INN]
Common Name English
REPAGERMANIUM
INCI   INN  
INCI   INN  
Official Name English
BIS (2-CARBOXYETHYLGERMANIUM)SESQUIOXIDE
Common Name English
RAPAGERMANIUM
Common Name English
.BETA.-CARBOXYETHYLGERMANIUM SESQUIOXIDE
Common Name English
ORGANIC GERMANIUM
Common Name English
PROPANOIC ACID, 3,3'-(1,3-DIOXO-1,3-DIGERMOXANEDIYL)BIS-
Common Name English
PROPAGERMANIUM [JAN]
Common Name English
PROPAGERMANIUM [INCI]
Common Name English
PROXIGERMANIUM
Common Name English
CARBOXYETHYLGERMANIUM SESQUIOXIDE
Common Name English
ARLAMOL GEO
Brand Name English
REPAGERMANIUM [JAN]
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/18/2100
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
FDA ORPHAN DRUG 496715
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
Code System Code Type Description
EVMPD
SUB35908
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
MERCK INDEX
m9179
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY Merck Index
INN
6259
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
ALTERNATIVE
CAS
126595-07-1
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
ALTERNATIVE
ECHA (EC/EINECS)
235-800-0
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
DAILYMED
1Q2P9TO9Q7
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
NCI_THESAURUS
C171759
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
NSC
267004
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
FDA UNII
1Q2P9TO9Q7
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
WIKIPEDIA
PROPAGERMANIUM
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
ChEMBL
CHEMBL2109214
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107883
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
RXCUI
158660
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY RxNorm
CAS
12758-40-6
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
MESH
C066750
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
EPA CompTox
DTXSID9065316
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
INN
6260
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY
CHEBI
32060
Created by admin on Sat Dec 16 05:18:01 GMT 2023 , Edited by admin on Sat Dec 16 05:18:01 GMT 2023
PRIMARY