Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2C3H5GeO2.3O |
Molecular Weight | 339.42 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[O--].[O--].[O--].OC(=O)CC[Ge+3].OC(=O)CC[Ge+3]
InChI
InChIKey=ZBANESJQZVORBE-UHFFFAOYSA-N
InChI=1S/2C3H5GeO2.3O/c2*4-2-1-3(5)6;;;/h2*1-2H2,(H,5,6);;;/q2*+3;3*-2
Molecular Formula | O |
Molecular Weight | 15.9994 |
Charge | -2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C3H5GeO2 |
Molecular Weight | 145.71 |
Charge | 3 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://cam-cancer.org/layout/set/print/layout/set/pdf/The-Summaries/Dietary-approaches/Propagermanium/(merge)Curator's Comment: description was created based on several sources, including:
http://www.rad-ar.or.jp/siori/english/kekka_plain.cgi?n=1339 |https://www.ncbi.nlm.nih.gov/pubmed/12825127
Sources: http://cam-cancer.org/layout/set/print/layout/set/pdf/The-Summaries/Dietary-approaches/Propagermanium/(merge)
Curator's Comment: description was created based on several sources, including:
http://www.rad-ar.or.jp/siori/english/kekka_plain.cgi?n=1339 |https://www.ncbi.nlm.nih.gov/pubmed/12825127
Propagermanium, a newly introduced hydrophilic polymer of 3-oxygermanium propionic acid (3,3’-(1,3- dioxo-1,3-digermoxanediyl) bispropionic acid) has been reported to have antiinflammatory, antiviral and antineoplastic properties. In Japan propagermanium is approved for the treatment of HBe positive chronic hepatitis B. A postmarketing survey, however, revealed the occurrence of moderate to severe liver damage after the treatment in about 4% of patients. In most countries propagermanium falls under the regulations of dietary supplements. An import alert on germanium products was imposed by the U.S. FDA in 1988, because of possible injury to health. In Germany governmental institutions warned consumers of possibly fatal kidney damage.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL4015 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | SEROCION Approved UseIt is approved for the treatment of HBe positive chronic hepatitis B. |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
Sample Use Guides
30 mg per day (10 mg of the active ingredient at a time, 3 times daily, after meal)
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11440636
THP-1 cells were incubated with propagermanium at 37°C for 15 min in 5% CO2. The cells (5 x 10^6 cells/25 ul) were mixed with 125I-MCP-1 (227 pM, 25 ul) at 25°C for 45 min. Propagermanium at concentrations 0.1, 0.3 and 1mg/ml prevents MCP-1-induced chemotaxis of THP-1 cells and human PBMC.
Substance Class |
Chemical
Created
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admin
on
Edited
Sat Dec 16 05:18:01 GMT 2023
by
admin
on
Sat Dec 16 05:18:01 GMT 2023
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Record UNII |
1Q2P9TO9Q7
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Record Status |
Validated (UNII)
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Record Version |
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EU-Orphan Drug |
EU/3/18/2100
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FDA ORPHAN DRUG |
496715
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SUB35908
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m9179
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6259
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126595-07-1
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1Q2P9TO9Q7
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C171759
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267004
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PROPAGERMANIUM
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CHEMBL2109214
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12758-40-6
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C066750
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DTXSID9065316
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