CETRIMONIUM TOSYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H42N.C7H7O3S
Molecular Weight	455.737
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(C=C1)S([O-])(=O)=O.CCCCCCCCCCCCCCCC[N+](C)(C)C

InChI

InChIKey=MZMRZONIDDFOGF-UHFFFAOYSA-M

InChI=1S/C19H42N.C7H8O3S/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4;1-6-2-4-7(5-3-6)11(8,9)10/h5-19H2,1-4H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

HIDE SMILES / InChI

Description
Sources: http://www.sciencedirect.com/science/article/pii/S0140673600701000
Curator's Comment: Description was created based on several sources, including http://www.americanpharmaceuticalreview.com/Featured-Articles/38886-Antimicrobial-Preservatives-Part-One-Choosing-a-Preservative-System/ | https://books.google.ru/books?id=EMrSBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.ncbi.nlm.nih.gov/pubmed/9880479 | http://www.medindia.net/doctors/drug_information/cetrimide.htm

Cetrimide is a quaternary ammonium compound. Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). Cetrimide combines excellent detergent properties and minimal toxicity with a useful antiseptic action. Cetrimide affects membrane permeability allowing ‘leaking’ of essential cell constituents leading to cell death. This medication is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
hepatocyte cell migration 9 Target ID: GO:0002194 Sources: https://www.ncbi.nlm.nih.gov/pubmed/31262888	Inhibitor 8297
Cell membrane 42 Target ID: CHEMBL2364031 Sources: http://www.americanpharmaceuticalreview.com/Featured-Articles/38886-Antimicrobial-Preservatives-Part-One-Choosing-a-Preservative-System/ \| https://www.ncbi.nlm.nih.gov/pubmed/9880479	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Skin infections 59 Sources: http://www.medindia.net/doctors/drug_information/cetrimide.htm	Curative		Approved 8429	CETRIMIDE Approved Use Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
Seborrheic dermatitis 15 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13453100	Primary		Approved 8429	CETRIMIDE Approved Use Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Wound cleansing - Topical : Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area. Seborrhoeic dermatitis - Topical : Adult: Apply 10% shampoo solution onto the scalp.

Route of Administration: Topical

In Vitro Use Guide

Cetrimide, at 30 ug/ml inhibited growth of Aspergillus niger.

Name

Type

Language

CETRIMONIUM TOSYLATE

Official Name

English

TRIMETHYLCETYLAMMONIUM-P-TOLUOLSULFONAT

Common Name

English

1-HEXADECANAMINIUM, N,N,N-TRIMETHYL-, 4-METHYLBENZENESULFONATE (1:1)

Systematic Name

English

QUATROL

Common Name

English

CETYLTRIMETHYLAMMONIUM TOSYLATE

Systematic Name

English

Cetyltrimethylammonium p-toluenesulfonate [WHO-DD]

Common Name

English

1-HEXADECANAMINIUM, N,N,N-TRIMETHYL-, SALT WITH 4-METHYLBENZENESULFONIC ACID (1:1)

Common Name

English

CETYLTRIMETHYLAMMONIUM 4-TOLUENESULFONATE

Systematic Name

English

CETRIMONIUM TOSYLATE [INCI]

Common Name

English

TRIMETHYL CETYL AMMONIUM P-TOLUENESULFONATE

Common Name

English

AMMONIUM, HEXADECYLTRIMETHYL-, P-TOLUENESULFONATE

Common Name

English

CTAOTOS

Common Name

English

HEXADECYLTRIMETHYLAMMONIUM TOSYLATE

Systematic Name

English

CETATS

Brand Name

English

CETYLTRIMETHYLAMMONIUM P-TOLUENESULFONATE

Common Name

English

CETRIMONIUM BROMIDE P-TOLUENESULFONATE ANALOG [MI]

Common Name

English

HEXADECYLTRIMETHYLAMMONIUM P-TOSYLATE

Common Name

English

TRICETOL

Common Name

English

Code System Code Type Description

EVMPD

SUB61495