U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry RACEMIC
Molecular Formula C5H10O4
Molecular Weight 134.1305
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCERYL 1-ACETATE

SMILES

CC(=O)OCC(O)CO

InChI

InChIKey=KMZHZAAOEWVPSE-UHFFFAOYSA-N
InChI=1S/C5H10O4/c1-4(7)9-3-5(8)2-6/h5-6,8H,2-3H2,1H3

HIDE SMILES / InChI

Description

Glyceryl 1-acetate is a glycerol ester. It potently inhibits aquaporin-mediated glycerol uptakes. Glyceryl 1-acetate was primarily used as an antidote in fluoroacetate poisoning because it was believed that acetate exerted a protective effect via competition with fluoroacetate for binding with coenzyme A. Glyceryl 1-acetate has been superseded by acetamide therapy. Glycerol 1-Acetate is a derivative of Triacetin, which is used as a food additive and flavoring.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
134.0 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Rat: 0.3 ml
Route of Administration: Intraperitoneal
In Vitro Use Guide
The glycerol analogues GLYCERYL 1-ACETATE was able in a concentration-dependent manner to inhibit glycerol uptake into rat hepatocytes with IC50 values of approximately 1 mM.