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Details

Stereochemistry RACEMIC
Molecular Formula C5H10O4
Molecular Weight 134.1305
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLYCERYL 1-ACETATE

SMILES

CC(=O)OCC(O)CO

InChI

InChIKey=KMZHZAAOEWVPSE-UHFFFAOYSA-N
InChI=1S/C5H10O4/c1-4(7)9-3-5(8)2-6/h5-6,8H,2-3H2,1H3

HIDE SMILES / InChI

Description

Glyceryl 1-acetate is a glycerol ester. It potently inhibits aquaporin-mediated glycerol uptakes. Glyceryl 1-acetate was primarily used as an antidote in fluoroacetate poisoning because it was believed that acetate exerted a protective effect via competition with fluoroacetate for binding with coenzyme A. Glyceryl 1-acetate has been superseded by acetamide therapy. Glycerol 1-Acetate is a derivative of Triacetin, which is used as a food additive and flavoring.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
134.0 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Rat: 0.3 ml
Route of Administration: Intraperitoneal
In Vitro Use Guide
The glycerol analogues GLYCERYL 1-ACETATE was able in a concentration-dependent manner to inhibit glycerol uptake into rat hepatocytes with IC50 values of approximately 1 mM.