GLYCERYL 1-ACETATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C5H10O4
Molecular Weight	134.1305
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)OCC(O)CO

InChI

InChIKey=KMZHZAAOEWVPSE-UHFFFAOYSA-N

InChI=1S/C5H10O4/c1-4(7)9-3-5(8)2-6/h5-6,8H,2-3H2,1H3

HIDE SMILES / InChI

Molecular Formula	C5H10O4
Molecular Weight	134.1305
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16119418 | https://www.ncbi.nlm.nih.gov/pubmed/24492673 | https://www.ncbi.nlm.nih.gov/pubmed/21691092 | DOI: 10.1039/C3GC42032A

Glyceryl 1-acetate is a glycerol ester. It potently inhibits aquaporin-mediated glycerol uptakes. Glyceryl 1-acetate was primarily used as an antidote in fluoroacetate poisoning because it was believed that acetate exerted a protective effect via competition with fluoroacetate for binding with coenzyme A. Glyceryl 1-acetate has been superseded by acetamide therapy. Glycerol 1-Acetate is a derivative of Triacetin, which is used as a food additive and flavoring.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Aquaporin-9 1 Target ID: O43315 Gene ID: 366.0 Gene Symbol: AQP9 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18762715	Inhibitor 8504
Aquaporin-7 1 Target ID: O14520 Gene ID: 364.0 Gene Symbol: AQP7 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/24492673	Inhibitor 8504	134.0 µM [Ki]
Aquaporin-10 1 Target ID: Q96PS8 Gene ID: 89872.0 Gene Symbol: AQP10 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21691092	Inhibitor 8504
Ccoenzyme A 1 Target ID: Ccoenzyme A Sources: https://www.ncbi.nlm.nih.gov/pubmed/16119418	Binding Agent 1076

Conditions

Condition	Modality	Targets	Highest Phase	Product
Fluoroacetate poisoning 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5880542 https://www.ncbi.nlm.nih.gov/pubmed/6578725 https://www.ncbi.nlm.nih.gov/pubmed/1437742 https://www.ncbi.nlm.nih.gov/pubmed/16119418	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Determination of the composition of acetylglycerol mixtures by (1)H NMR followed by GC investigation.	2008-11-15	18947192
The effect of monoacetin and calcium chloride on acid-base balance and survival in experimental sodium fluoroacetate poisoning.	1983	6578725
Human milk bile salt-activated lipase. Further characterization and kinetic studies.	1981-10-10	7275975

Patents

Sample Use Guides

In Vivo Use Guide

Rat: 0.3 ml

Route of Administration: Intraperitoneal

In Vitro Use Guide

The glycerol analogues GLYCERYL 1-ACETATE was able in a concentration-dependent manner to inhibit glycerol uptake into rat hepatocytes with IC50 values of approximately 1 mM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:00:59 GMT 2025` Edited by `admin` on `Mon Mar 31 22:00:59 GMT 2025`
Record UNII	1NA86SF2H2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLYCERYL 1-ACETATE

Common Name

English

NSC-35010

Preferred Name

English

1-MONOACETIN [USP IMPURITY]

Common Name

English

ACETIN, 1-MONO-

Systematic Name

English

1,2,3-PROPANETRIOL, 1-ACETATE

Common Name

English

1-MONOACETIN

Common Name

English

MONOACETYL GLYCERINE

Systematic Name

English

GLYCERYL 1-MONOACETATE

Common Name

English

ACETIC ACID, MONOGLYCERIDE

Common Name

English

(±)-2,3-DIHYDROXYPROPYL ACETATE

Systematic Name

English

.ALPHA.-MONOACETIN

Common Name

English

GLYCEROL .ALPHA.-MONOACETATE

Common Name

English

Code System Code Type Description

CAS

106-61-6