Details
Stereochemistry | RACEMIC |
Molecular Formula | C17H25NO2 |
Molecular Weight | 275.3859 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(=O)O[C@]1(C[C@H](C)N(C)C[C@H]1C)C2=CC=CC=C2
InChI
InChIKey=UVITTYOJFDLOGI-KEYYUXOJSA-N
InChI=1S/C17H25NO2/c1-5-16(19)20-17(15-9-7-6-8-10-15)11-14(3)18(4)12-13(17)2/h6-10,13-14H,5,11-12H2,1-4H3/t13-,14+,17+/m1/s1
Trimeperidine (promedol) is the earliest and mostly studied opioid analgesic. Trimeperidine stimulates opioid receptors in the central nervous system. Compared with morphine, it has a weaker and shorter analgesic effect, less affects the respiratory, vomiting and vagal centers, does not cause smooth muscle spasm (except for the myometrium), and has a moderate antispasmodic and hypnotic effect. It is used to treat severe pain syndrome, acute left ventricular failure, pulmonary edema, cardiogenic shock, preparation for surgery, childbirth, high fever, post-transfusion complications, poisoning with atropine, barbiturates, barium, gasoline, boric acid, strong acids, carbon monoxide, turpentine, formalin, formalin. It has several side effects. Administration of this substance is associated with the development of life-threatening conditions accompanied by the suppression of respiration center. Analgesic trimeperidine (promedol) was included into the health care kits by various Ministries of the Russian Federation at different times.
Approval Year
PubMed
Title | Date | PubMed |
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[Use of lornoxicam for analgesia in the early postoperative period]. | 2001 May-Jun |
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[Clinical aspects of using patient-controlled analgesia with nonsteroidal anti-inflammatory agents in postoperative period]. | 2003 Sep-Oct |
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[Postoperative analgesia with nonsteroid anti-inflammatory drugs in children]. | 2004 Jan-Feb |
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[Analgesic and opioid-sparing effects of intravenous paracetamol in the early period after aortocoronary bypass surgery]. | 2008 Sep-Oct |
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[Comparison of analgesics using two devices for the patient-controlled analgesia]. | 2009 Jul-Aug |
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[Impact of preemptive analgesia on postoperative pain syndrome in laparoscopic surgery]. | 2009 Nov-Dec |
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[Anesthetic maintenance during circular face lifting]. | 2010 Mar-Apr |
Patents
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C67413
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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DEA NO. |
9646
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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Code System | Code | Type | Description | ||
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20055107
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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200-583-3
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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64-39-1
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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NON-SPECIFIC STEREOCHEMISTRY | |||
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TRIMEPERIDINE
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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SUB11303MIG
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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C76848
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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1M2IB31DTS
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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713
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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m9169
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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CHEMBL2107685
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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100000076922
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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DTXSID501018271
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY | |||
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29606-10-8
Created by
admin on Fri Dec 15 16:36:42 UTC 2023 , Edited by admin on Fri Dec 15 16:36:42 UTC 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)