U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C29H28F4N4O4
Molecular Weight 572.5506
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LETERMOVIR

SMILES

COC1=CC=CC(=C1)N2CCN(CC2)C3=NC4=C(F)C=CC=C4[C@H](CC(O)=O)N3C5=CC(=CC=C5OC)C(F)(F)F

InChI

InChIKey=FWYSMLBETOMXAG-QHCPKHFHSA-N
InChI=1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1

HIDE SMILES / InChI

Approval Year

Name Type Language
LETERMOVIR
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
AIC246
Code English
LETERMOVIR [WHO-DD]
Common Name English
(4S)-2-(8-FLUORO-2-(4-(3-METHOXYPHENYL)PIPERAZIN-1-YL)-3-(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)-3,4-DIHYDROQUINAZOLIN-4-YL)ACETIC ACID
Systematic Name English
4-QUINAZOLINEACETIC ACID, 8-FLUORO-3,4-DIHYDRO-2-(4-(3-METHOXYPHENYL)-1-PIPERAZINYL)-3-(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)-, (4S)-
Common Name English
MK-8228
Code English
2-((4S)-8-FLUORO-2-(4-(3-METHOXYPHENYL)PIPERAZIN-1-YL)-3-(2-METHOXY-5-(TRIFLUOROMETHYL)PHENYL)-4H-QUINAZOLIN-4-YL)ACETIC ACID
Systematic Name English
AIC-246
Code English
LETERMOVIR [JAN]
Common Name English
LETERMOVIR [INN]
Common Name English
AIC 246
Code English
LETERMOVIR [USAN]
Common Name English
PREVYMIS
Brand Name English
Code System Code Type Description
EPA CompTox
917389-32-3
Created by admin on Tue Mar 06 10:56:20 UTC 2018 , Edited by admin on Tue Mar 06 10:56:20 UTC 2018
PRIMARY
WIKIPEDIA
LETERMOVIR
Created by admin on Tue Mar 06 10:56:20 UTC 2018 , Edited by admin on Tue Mar 06 10:56:20 UTC 2018
PRIMARY
CAS
917389-32-3
Created by admin on Tue Mar 06 10:56:20 UTC 2018 , Edited by admin on Tue Mar 06 10:56:20 UTC 2018
PRIMARY
ChEMBL
CHEMBL1241951
Created by admin on Tue Mar 06 10:56:20 UTC 2018 , Edited by admin on Tue Mar 06 10:56:20 UTC 2018
PRIMARY
EVMPD
SUB90389
Created by admin on Tue Mar 06 10:56:20 UTC 2018 , Edited by admin on Tue Mar 06 10:56:20 UTC 2018
PRIMARY
EU-Orphan Drug
EU/3/11/849(POSITIVE)
Created by admin on Tue Mar 06 10:56:20 UTC 2018 , Edited by admin on Tue Mar 06 10:56:20 UTC 2018
PRIMARY On 15 April 2011, orphan designation (EU/3/11/849) was granted by the European Commission to AiCuris GmbH & Co. KG, Germany, for (S)-{8-fluoro-2-2[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)-phenyl]-3, 4-dihydro-4-quinazolinyl} acetic acid for the prevention of cytomegalovirus disease in patients with impaired cell-mediated immunity deemed at risk. The sponsorship was transferred to Merck Sharp & Dohme Limited, United Kingdom, in March 2013.
PUBCHEM
45138674
Created by admin on Tue Mar 06 10:56:20 UTC 2018 , Edited by admin on Tue Mar 06 10:56:20 UTC 2018
PRIMARY SWITZERF
INN
9384
Created by admin on Tue Mar 06 10:56:20 UTC 2018 , Edited by admin on Tue Mar 06 10:56:20 UTC 2018
PRIMARY