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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H17N3O2S
Molecular Weight 303.379
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PUMOSETRAG

SMILES

O=C(N[C@H]1CN2CCC1CC2)C3=CNC4=C(SC=C4)C3=O

InChI

InChIKey=AFUWQWYPPZFWCO-LBPRGKRZSA-N
InChI=1S/C15H17N3O2S/c19-13-10(7-16-11-3-6-21-14(11)13)15(20)17-12-8-18-4-1-9(12)2-5-18/h3,6-7,9,12H,1-2,4-5,8H2,(H,16,19)(H,17,20)/t12-/m0/s1

HIDE SMILES / InChI
Pumosetrag is a novel, orally active and selective 5-HT 3 agonist. It is a partial agonist in rats and guinea-pig and a full agonist in the mouse, suggesting important species differences in 5-HT3 receptor structure. Pumosetrag had been in phase II clinical trials for the treatment of gastroesophageal reflux disease and irritable bowel syndrome. No serious adverse events were reported. Diarrhea was not more common on the drug and only one subject experienced pruritus. All researches on this drug candidate are discontinued.

Approval Year

Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
inconclusive [IC50 >10 uM]
inconclusive [IC50 >10 uM]
inconclusive [IC50 >10 uM]
inconclusive [IC50 >10 uM]
inconclusive [IC50 >10 uM]
yes [IC50 9.3 uM]
PubMed

PubMed

TitleDatePubMed
Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans.
2003 Nov 15
Drug evaluation: Pumosetrag for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
2007 May
Novel partial 5HT3 agonist pumosetrag reduces acid reflux events in uninvestigated GERD patients after a standard refluxogenic meal: a randomized, double-blind, placebo-controlled pharmacodynamic study.
2014 Jan
Patents

Patents

Sample Use Guides

0.2, 0.5, or 0.8 mg
Route of Administration: Oral
In the presence of methysergide (1 mol/l) and GR125487 (0.1 mol/l), MKC-733 appeared to have little to no contractile effect in the jejunum (E max = 11.85 %), ileum (E max = 9.65 %) and distal colon of the rat (E max = 14.30 %).
Name Type Language
PUMOSETRAG
INN  
INN  
Official Name English
N-((3R)-1-AZABICYCLO(2.2.2)OCT-3-YL)-7-OXO-4,7-DIHYDROTHIENO(3,2-B)PYRIDINE-6-CARBOXAMIDE
Systematic Name English
pumosetrag [INN]
Common Name English
THIENO(3,2-B)PYRIDINE-6-CARBOXAMIDE, N-(3R)-1-AZABICYCLO(2.2.2)OCT-3-YL-4,7-DIHYDRO-7-OXO-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C47794
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C84126
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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EPA CompTox
DTXSID70165211
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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INN
8217
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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SMS_ID
300000036978
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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CAS
153062-94-3
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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FDA UNII
1G26B32139
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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ChEMBL
CHEMBL1643880
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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PUBCHEM
154104
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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MESH
C482040
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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DRUG BANK
DB12402
Created by admin on Fri Dec 15 16:28:21 GMT 2023 , Edited by admin on Fri Dec 15 16:28:21 GMT 2023
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