DescriptionCurator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf
Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2364036 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | BACITRACIN Approved UseUses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date1948 |
|||
| Curative | CORTISPORIN Approved UseFor the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date1957 |
|||
| Curative | NEOSPORIN Approved UseNEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date1968 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity. | 1992 Dec |
|
| Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes. | 1992 Jul 15 |
|
| [Effect of zinc deficiency and zinc replenishment on HOX3.5 gene expression in mouse embryos]. | 2001 Nov |
|
| Metallothionein is required for zinc-induced expression of the macrophage colony stimulating factor gene. | 2002 |
|
| p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells. | 2002 Aug |
|
| Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells. | 2002 Aug |
|
| Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase. | 2002 Dec |
|
| Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle. | 2002 Dec 13 |
|
| S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation. | 2002 Jul 2 |
|
| Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. | 2002 Jul 5 |
|
| Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina. | 2002 Jun 30 |
|
| Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively. | 2002 May 14 |
|
| Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents. | 2002 Nov |
|
| Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation. | 2002 Nov |
|
| Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation. | 2002 Oct |
|
| Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). | 2002 Oct 25 |
|
| Evidence for non-isostructural replacement of Zn(2+) with Cd(2+) in the beta-domain of brain-specific metallothionein-3. | 2002 Sep 11 |
|
| Induction of metallothionein by zinc protects from daunorubicin toxicity in rats. | 2002 Sep 30 |
|
| Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform. | 2003 Apr |
|
| Effect of chromium on apolipoprotein A-I expression in HepG2 cells. | 2003 Apr |
|
| Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays. | 2003 Apr |
|
| Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. | 2003 Aug |
|
| Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. | 2003 Aug 1 |
|
| Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor. | 2003 Aug 15 |
|
| Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3. | 2003 Aug 19 |
|
| The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. | 2003 Aug 29 |
|
| Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. | 2003 Dec 5 |
|
| Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes. | 2003 Feb 15 |
|
| Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. | 2003 Feb 4 |
|
| Activation of the rainbow trout metallothionein-A promoter by silver and zinc. | 2003 Jan |
|
| The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion. | 2003 Jan |
|
| Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice. | 2003 Jan |
|
| p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. | 2003 Jan 1 |
|
| A novel class of ligand-gated ion channel is activated by Zn2+. | 2003 Jan 10 |
|
| Differential effects of zinc on functionally distinct human growth hormone mutations. | 2003 Jul |
|
| Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1. | 2003 Jul 11 |
|
| In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites. | 2003 Jun |
|
| Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein. | 2003 Jun |
|
| Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. | 2003 Mar |
|
| Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase. | 2003 May 2 |
|
| Zinc modulates mRNA levels of cytokines. | 2003 Nov |
|
| Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. | 2003 Nov 14 |
|
| Zinc modulates PPARgamma signaling and activation of porcine endothelial cells. | 2003 Oct |
|
| Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. | 2003 Oct 1 |
|
| Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. | 2003 Oct 3 |
|
| Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate. | 2003 Oct 3 |
|
| Purification of recombinant human apometallothionein-3 and reconstitution with zinc. | 2003 Sep |
|
| O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. | 2003 Sep 23 |
|
| Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. | 2004 Apr |
|
| Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants. | 2004 Mar |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Bacitracin can be used as ophtalmic solution (0.025mg/ml) for the treatment of superficial ocular infections.
400 units, topically
Route of Administration:
Topical
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
m2198
Created by
admin on Sat Dec 16 07:51:12 GMT 2023 , Edited by admin on Sat Dec 16 07:51:12 GMT 2023
|
PRIMARY | Merck Index | ||
|
1EJ7TZQ03Q
Created by
admin on Sat Dec 16 07:51:12 GMT 2023 , Edited by admin on Sat Dec 16 07:51:12 GMT 2023
|
PRIMARY |
All of the following components must be present:
ACTIVE MOIETY
SUBSTANCE RECORD