GLYBUZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H15N3O2S2
Molecular Weight	297.396
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)C1=NN=C(NS(=O)(=O)C2=CC=CC=C2)S1

InChI

InChIKey=NMWQEPCLNXHPDX-UHFFFAOYSA-N

InChI=1S/C12H15N3O2S2/c1-12(2,3)10-13-14-11(18-10)15-19(16,17)9-7-5-4-6-8-9/h4-8H,1-3H3,(H,14,15)

HIDE SMILES / InChI

Description
Sources: doi.org/10.11213/tonyobyo1958.18.149

Glybuzole is a sulfonamide derivative with antihyperglycemic activity is used as antidiabetic. Glybuzole is able to lower blood glucose levels by increasing the release of insulin from pancreatic beta cells.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
insulin secretion 8 Target ID: GO:0030073 Sources: doi.org/10.11213/tonyobyo1958.18.149	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes mellitus 91 Sources: http://www.ncbi.nlm.nih.gov/pubmed/5090443	Primary		Preclinical	Gludiase Approved Use Unknown

PubMed

Title	Date	PubMed
[Death caused by intravenous anesthetics; thoracic pain caused by synthetic penicillin; and liver diseases induced by Glybuzole sometimes used in combination with clindamycin for the treatment of diabetes by dentists in the form of self medication].	1976	1071098

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

GLYBUZOLE

Official Name

English

RP 7891

Code

English

AN-1324

Code

English

N-(5-TERT-BUTYL-1,3,4-THIADIAZOL-2-YL)BENZENESULFONAMIDE

Systematic Name

English

GLUDIASE

Brand Name

English

GLYBUZOLE [MI]

Common Name

English

GLYBUZOLE [MART.]

Common Name

English

RP-7891

Code

English

glybuzole [INN]

Common Name

English

Glybuzole [WHO-DD]

Common Name

English

AN 1324

Code

English

GLYBUZOLE [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29711