LOTIFAZOLE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H9Cl3N2O2S
Molecular Weight	351.636
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LOTIFAZOLE

Structure Search

SMILES

ClC(Cl)(Cl)COC(=O)NC1=NC(=CS1)C2=CC=CC=C2

InChI

InChIKey=SMQXDOVGKKMUIZ-UHFFFAOYSA-N

InChI=1S/C12H9Cl3N2O2S/c13-12(14,15)7-19-11(18)17-10-16-9(6-20-10)8-4-2-1-3-5-8/h1-6H,7H2,(H,16,17,18)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6702514 | https://link.springer.com/book/10.1007/978-1-4757-2085-3

Lotifazole (F 1686) - 4-phenyl-2-(2',2',2-trichloroethoxycarboxamido) thiazole is an immunostimulant. It has a range of anti-inflammatory activities in animals that differs from the activities of classic non-steroidal drugs.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Potential antitumor agents XIX [1]. Synthesis and antitumor activity of tricyclic compounds related to lotifazole.	1992	1384067
Lotifazole (F 1686), a non-steroidal anti-inflammatory agent with an unusual pharmacological spectrum.	1984-01	6702514

Name

Type

Language

LOTIFAZOLE

Official Name

English

NSC-358482

Preferred Name

English

lotifazole [INN]

Common Name

English

2,2,2-TRICHLOROETHYL 4-PHENYL-2-THIAZOLECARBAMATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257

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Code System Code Type Description

CAS

71119-10-3

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FDA UNII

1B3TF200TI

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MESH

C040605

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INN

4801

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PUBCHEM

68905

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EVMPD

SUB08600MIG

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EPA CompTox

DTXSID10221325

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ChEMBL

CHEMBL2105113

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NSC

358482

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NCI_THESAURUS

C66037

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SMS_ID

100000082039

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ACTIVE MOIETY


					1B3TF200TI