LOTIFAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H9Cl3N2O2S
Molecular Weight	351.636
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC(Cl)(Cl)COC(=O)NC1=NC(=CS1)C2=CC=CC=C2

InChI

InChIKey=SMQXDOVGKKMUIZ-UHFFFAOYSA-N

InChI=1S/C12H9Cl3N2O2S/c13-12(14,15)7-19-11(18)17-10-16-9(6-20-10)8-4-2-1-3-5-8/h1-6H,7H2,(H,16,17,18)

HIDE SMILES / InChI

Molecular Formula	C12H9Cl3N2O2S
Molecular Weight	351.636
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6702514 | https://link.springer.com/book/10.1007/978-1-4757-2085-3

Lotifazole (F 1686) - 4-phenyl-2-(2',2',2-trichloroethoxycarboxamido) thiazole is an immunostimulant. It has a range of anti-inflammatory activities in animals that differs from the activities of classic non-steroidal drugs.

Approval Year

PubMed

Title	Date	PubMed
Potential antitumor agents XIX [1]. Synthesis and antitumor activity of tricyclic compounds related to lotifazole.	1992	1384067
Lotifazole (F 1686), a non-steroidal anti-inflammatory agent with an unusual pharmacological spectrum.	1984-01	6702514

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:08:25 GMT 2025` Edited by `admin` on `Mon Mar 31 18:08:25 GMT 2025`
Record UNII	1B3TF200TI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOTIFAZOLE

Official Name

English

NSC-358482

Preferred Name

English

lotifazole [INN]

Common Name

English

2,2,2-TRICHLOROETHYL 4-PHENYL-2-THIAZOLECARBAMATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257