Details
Stereochemistry | ACHIRAL |
Molecular Formula | C23H28ClN3O2 |
Molecular Weight | 413.94 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2CCC(=O)N(CCCN3CCN(CC3)C4=CC(Cl)=CC=C4)C2=CC=C1
InChI
InChIKey=TZZGTNZBLPCBIS-UHFFFAOYSA-N
InChI=1S/C23H28ClN3O2/c1-29-22-8-3-7-21-20(22)9-10-23(28)27(21)12-4-11-25-13-15-26(16-14-25)19-6-2-5-18(24)17-19/h2-3,5-8,17H,4,9-16H2,1H3
Approval Year
PubMed
Title | Date | PubMed |
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Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. | 2001 Dec |
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Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate). | 2002 Apr |
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Potential antidepressant activity of sigma ligands. | 2003 Nov-Dec |
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Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. | 2004 Aug |
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Behavioral pharmacology of sigma-ligands. | 2004 Nov |
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In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. | 2005 Jul 11 |
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Effects of OPC-14523, a combined sigma and 5-HT1a ligand, on pre- and post-synaptic 5-HT1a receptors. | 2007 Jan |
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1981OTB4DS
Created by
admin on Sat Dec 16 13:46:08 GMT 2023 , Edited by admin on Sat Dec 16 13:46:08 GMT 2023
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9892540
Created by
admin on Sat Dec 16 13:46:08 GMT 2023 , Edited by admin on Sat Dec 16 13:46:08 GMT 2023
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DB05422
Created by
admin on Sat Dec 16 13:46:08 GMT 2023 , Edited by admin on Sat Dec 16 13:46:08 GMT 2023
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145969-30-8
Created by
admin on Sat Dec 16 13:46:08 GMT 2023 , Edited by admin on Sat Dec 16 13:46:08 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)