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Details

Stereochemistry ACHIRAL
Molecular Formula C29H27F2N3O
Molecular Weight 471.541
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SEGANSERIN

SMILES

CC1=C(CCN2CCC(CC2)=C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C(=O)N5C=CC=CC5=N1

InChI

InChIKey=ZGUPMFYFHHSNFK-UHFFFAOYSA-N
InChI=1S/C29H27F2N3O/c1-20-26(29(35)34-16-3-2-4-27(34)32-20)15-19-33-17-13-23(14-18-33)28(21-5-9-24(30)10-6-21)22-7-11-25(31)12-8-22/h2-12,16H,13-15,17-19H2,1H3

HIDE SMILES / InChI
Seganserin was developed as a specific serotonin 5HT2 receptor antagonist. It was tested neuropharmacologically in thioacetamide-induced acute liver failure in rats. Obtained results have shown that seganserin had no effect in encephalopathic rats.

Approval Year

PubMed

PubMed

TitleDatePubMed
Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and 5-HT2-receptors: comparison with ketanserin.
1986 May
Effects of seganserin, a 5-HT2 antagonist, and temazepam on human sleep stages and EEG power spectra.
1989 Nov 21
Modulation of hepatic encephalopathy in rats with thioacetamide-induced acute liver failure by serotonin antagonists.
1996 Jul
Effect of 5-HT1A and 5-HT2A/2C receptor modulation on neuroleptic-induced vacuous chewing movements.
2001 Sep 28
Patents
Name Type Language
SEGANSERIN
INN  
INN  
Official Name English
seganserin [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66885
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C76967
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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FDA UNII
197HL4EZCC
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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INN
5497
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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EPA CompTox
DTXSID50236594
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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PUBCHEM
71767
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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ChEMBL
CHEMBL1742436
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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SMS_ID
100000084106
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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EVMPD
SUB10472MIG
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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CAS
87729-89-3
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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MESH
C046301
Created by admin on Fri Dec 15 15:41:56 GMT 2023 , Edited by admin on Fri Dec 15 15:41:56 GMT 2023
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