Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C19H11BrF2N2O4 |
| Molecular Weight | 449.202 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=CC2=C(C=C1)C(=O)N(CC3=C(F)C=C(Br)C=C3)C(=O)C24CC(=O)NC4=O
InChI
InChIKey=BMHZAHGTGIZZCT-UHFFFAOYSA-N
InChI=1S/C19H11BrF2N2O4/c20-10-2-1-9(14(22)5-10)8-24-16(26)12-4-3-11(21)6-13(12)19(18(24)28)7-15(25)23-17(19)27/h1-6H,7-8H2,(H,23,25,27)
Minalrestat was developed by Wyeth-Ayerst as an aldose reductase inhibitor. It is known, the aldose reductase inhibition might ameliorate diabetic complications through the correction of the altered microvascular reactivity by a mechanism that involves NO and membrane hyperpolarization. That is why minalrestat was studied for patients with diabetic retinopathy. However, Wyeth discontinued development of minalrestat.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy. | 1994 Sep |
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| Reversal of defective peripheral nerve conduction velocity, nutritive endoneurial blood flow, and oxygenation by a novel aldose reductase inhibitor, WAY-121,509, in streptozotocin-induced diabetic rats. | 1996 Jan-Feb |
|
| Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress. | 2009 Mar 16 |
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C72880
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C72820
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100000080637
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C473212
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ACTIVE MOIETY
