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Details

Stereochemistry ACHIRAL
Molecular Formula 2Cl.Co.6H2O
Molecular Weight 237.931
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS CHLORIDE HEXAHYDRATE

SMILES

O.O.O.O.O.O.[Cl-].[Cl-].[Co++]

InChI

InChIKey=GFHNAMRJFCEERV-UHFFFAOYSA-L
InChI=1S/2ClH.Co.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2

HIDE SMILES / InChI

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Brandt, G.
20
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Hypoxia-inducible factor 1-alpha inhibitor
22
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 1.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS.
1975 May 2
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.
1990 Aug
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
2005 Aug
Patents

Patents

US20150010463
20
US3459677 A
20
US4326084
20
US5718844
20
US6740618 B2
20
WO2014127808A1
20

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
In Vitro Use Guide
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Name Type Language
COBALTOUS CHLORIDE HEXAHYDRATE
MI  
Common Name English
COBALT CHLORIDE (COCL2), HEXAHYDRATE
Common Name English
Cobalt chloride hexahydrate [WHO-DD]
Common Name English
COBALT CHLORIDE, HEXAHYDRATE
Systematic Name English
COBALT CHLORIDE HEXAHYDRATE
WHO-DD  
Systematic Name English
COBALT(II) CHLORIDE HEXAHYDRATE
Systematic Name English
COBALT DICHLORIDE HEXAHYDRATE
Systematic Name English
COBALT(II) CHLORIDE, HEXAHYDRATE
Systematic Name English
COBALTOUS CHLORIDE HEXAHYDRATE [MI]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 189.120
Created by admin on Fri Dec 15 16:56:09 GMT 2023 , Edited by admin on Fri Dec 15 16:56:09 GMT 2023
Code System Code Type Description
DRUG BANK
DBSALT002759
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PRIMARY
EPA CompTox
DTXSID20999109
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PRIMARY
SMS_ID
100000128492
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PRIMARY
PUBCHEM
24643
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PRIMARY
FDA UNII
17AVG63ZBC
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PRIMARY
EVMPD
SUB35566
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PRIMARY
DAILYMED
17AVG63ZBC
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PRIMARY
MERCK INDEX
m3691
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PRIMARY Merck Index
CAS
7791-13-1
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PRIMARY
RXCUI
1426883
Created by admin on Fri Dec 15 16:56:09 GMT 2023 , Edited by admin on Fri Dec 15 16:56:09 GMT 2023
PRIMARY RxNorm
CHEBI
53503
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PRIMARY
NIH
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