Podophyllum resin is the powdered mixture of resins removed from the May apple or Mandrake, a perennial plant of the northern and middle United States. The early colonists learned of themedical properties of the root from the Indians, and it was used as a cathartic in the firstUnited States Pharmacopoeia (1820). The resin, podophyllin, was first separated from Podophyllum by John King in 1835. Between 1863 and 1942, podophyllin was reported to be a cathartic, purgative, deobstruent, vermifuge, hydragogue, cholagogue, choleretic, andexpectorant.Itwas recommended, either alone or in combination with other herbs, for diseases of the liverandkidneys, for scrofula, syphilis, gonorrhea, obstructed menstruation, urinary obstruction, dropsy, and coughs. Currently Podophyllum resin is used as a medication to treat genital warts and plantar warts, including in people with HIV/AIDS. Common side effects include redness, itchiness, and pain at the site of use. Severe side effects may include vomiting, abdominal pain, confusion, bone marrow suppression, and diarrhea. It is not recommended for more than a small area at a time. Use during pregnancy is known to be dangerous to the baby.
Approval Year
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CFR |
21 CFR 310.528
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NCI_THESAURUS |
C1331
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WHO-ESSENTIAL MEDICINES LIST |
13.4
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11979494
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16902YVY2B
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m8934
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5114
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C2362
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SUB14929MIG
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PODOPHYLLUM RESIN
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PRIMARY | Description: Light brown to greenish yellow or brownish grey masses or an amorphous powder. Solubility: Practically insoluble in cold water; partially soluble in hot water, and ether R; soluble in ethanol (~750 g/l) TS. Category: Keratolytic agent. Storage: Podophyllum resin should be kept in a tightly closed container, protected from light, and preferably stored at a temperature between 2 and 15 ?C. Labelling: The designation on the container should state the botanical source. Additional information: CAUTION: Podophyllum resin must be handled with care, avoiding contact with the skin and mucous membranes and inhalation of airborne particles. On exposure to light or to temperatures above 25 ?C, it becomes darker in colour. Definition: Podophyllum resin is a mixture of resins obtained from the rhizomes and roots of Podophyllum hexandrum Royle (P.emodi Wall.) or Podophyllum peltatum L. after percolation with ethanol and precipitation from water or very dilute acids. Podophyllum resin contains not less than 40.0% and not more than the equivalent of 52.5% of podophyllum toxin (α and β peltatum), calculated with reference to the dried substance. | ||
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DB09094
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232-546-2
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DTXSID101026250
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9000-55-9
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Podophyllum resin
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CHEMBL2108775
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16902YVY2B
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D011033
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8462
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PRIMARY | RxNorm |
ACTIVE MOIETY
