Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H26N2O3 |
| Molecular Weight | 306.3999 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)NCC(O)COC1=CC=CC2=C1CCN(C2)C=O
InChI
InChIKey=GMJHUSJLZXFFQJ-UHFFFAOYSA-N
InChI=1S/C17H26N2O3/c1-17(2,3)18-9-14(21)11-22-16-6-4-5-13-10-19(12-20)8-7-15(13)16/h4-6,12,14,18,21H,7-11H2,1-3H3
Soquinolol [WE 704] is a β-blocker that was under clinical development for the treatment of heart failure, but this research was discontinued. Soquinolol is a highly potent non-subtype-selective beta-adrenergic receptor blocker, which is devoid of any intrinsic sympathomimetic activity. Its local anaesthetic activity (membrane stabilizing effect) is very weak. It also shows good enteral efficacy and long duration of action. In binding studies with heart (Ki beta 1 = 3.25 nmol/l) and lung membranes (Ki beta 2 = 0.85 nmol/l) its binding profile was found to be similar to that of propranolol.
Approval Year
Sample Use Guides
In the conscious dog soquinolol's beta 1-adrenergic blocking activity (ED 50%) on intravenous injection (5.5 ug/kg) and oral administration (5.8 ug/kg) is about twice as great as that of pindolol and 19 times (i.v.) or 138 times (p.o.) greater than that of propranolol.
Route of Administration:
Other
In binding studies with heart (Ki beta 1 = 3.25 nmol/l) and lung membranes (Ki beta 2 = 0.85 nmol/l) Soquinolol's binding profile was found to be similar to that of propranolol. Soquinolol inhibits the isoprenaline-induced tachycardia (EC50% = 48 ug/l) in the guinea-pig Langendorff heart in vitro.
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NCI_THESAURUS |
C29576
Created by
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61563-18-6
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262-844-8
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CHEMBL1742453
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C058571
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68811
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C73019
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15CC9BOH7Q
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100000083790
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SUB10594MIG
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4761
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Soquinolol
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DTXSID00866865
Created by
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ACTIVE MOIETY
