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Details

Stereochemistry ABSOLUTE
Molecular Formula C13H11N3O4S
Molecular Weight 305.309
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of BLI-489 FREE ACID

SMILES

OC(=O)C1=CS[C@H]2N1C(=O)\C2=C\C3=CN4CCOCC4=N3

InChI

InChIKey=DMEYZPJEFHGESJ-CPWLGJMPSA-N
InChI=1S/C13H11N3O4S/c17-11-8(12-16(11)9(6-21-12)13(18)19)3-7-4-15-1-2-20-5-10(15)14-7/h3-4,6,12H,1-2,5H2,(H,18,19)/b8-3-/t12-/m1/s1

HIDE SMILES / InChI
BLI 489 was developed by Wyeth as a 6-methylidene-penem β-lactamase inhibitor for the treatment of bacterial infections and urinary tract infections. BLI-489 has shown the promising clinical data, however, development of this drug, was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Relationship between β-lactamase production and resistance phenotype in Klebsiella pneumoniae strains.
2017-07-06
Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489.
2009-02

Sample Use Guides

Unknown
Route of Administration: Intravenous
Name Type Language
BLI-489 FREE ACID
Common Name English
4-THIA-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID, 6-((5,6-DIHYDRO-8H-IMIDAZO(2,1-C)(1,4)OXAZIN-2-YL)METHYLENE)-7-OXO-, (5R,6Z)-
Preferred Name English
BLI 489 FREE ACID
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID60212945
Created by admin on Mon Mar 31 18:26:40 GMT 2025 , Edited by admin on Mon Mar 31 18:26:40 GMT 2025
PRIMARY
PUBCHEM
9972353
Created by admin on Mon Mar 31 18:26:40 GMT 2025 , Edited by admin on Mon Mar 31 18:26:40 GMT 2025
PRIMARY
CAS
635322-76-8
Created by admin on Mon Mar 31 18:26:40 GMT 2025 , Edited by admin on Mon Mar 31 18:26:40 GMT 2025
PRIMARY
FDA UNII
156B510BCG
Created by admin on Mon Mar 31 18:26:40 GMT 2025 , Edited by admin on Mon Mar 31 18:26:40 GMT 2025
PRIMARY