Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H16O5 |
| Molecular Weight | 276.2845 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C([C@H](O)[C@@H](O)C(C)=C)C2=C(C=CC(=O)O2)C=C1
InChI
InChIKey=DKEANOQWICTXTP-KBPBESRZSA-N
InChI=1S/C15H16O5/c1-8(2)13(17)14(18)12-10(19-3)6-4-9-5-7-11(16)20-15(9)12/h4-7,13-14,17-18H,1H2,2-3H3/t13-,14-/m0/s1
Minumicrolin and murrangatin are the diastereomeric isomers. They are 8-substituted 7-methoxycoumarins isolated from Murraya species. They were found to significantly inhibit EBV-EA activation, and preserved the high viability of Raji cells, suggesting that they might be valuable anti-tumor-promoting agents. Minumicrolin showed mild butyrylcholinesterase inhibition activity. It exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Coumarins and flavonoid from Murraya paniculata (L.) Jack: Antibacterial and anti-inflammation activity. | 2015-11 |
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| Coumarins from Murraya exotica collected in Egypt. | 2015-04 |
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| Coumarins from Murraya paniculata var. zollingeri endemic to the Timor Islands. | 2015-02 |
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| Cytotoxic compounds isolated from Murraya tetramera Huang. | 2014-08-27 |
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| C-7 oxygenated coumarins from the fruits of Micromelum minutum. | 2011-04 |
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| Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis. | 2010-05-28 |
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| Two new coumarins from Murraya paniculata. | 2008-05-13 |
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| Bioactive coumarins from the leaves of Murraya omphalocarpa. | 2003-07 |
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| Coumarin-related compounds as plant growth inhibitors from two rutaceous plants in Thailand. | 2000-02 |
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| Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay. | 1999-04-26 |
Patents
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13R570833L
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88546-96-7
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6426907
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admin on Mon Mar 31 21:56:31 GMT 2025 , Edited by admin on Mon Mar 31 21:56:31 GMT 2025
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SUBSTANCE RECORD
