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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H16O5
Molecular Weight 276.2845
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MINUMICROLIN

SMILES

COC1=CC=C2C=CC(=O)OC2=C1[C@H](O)[C@@H](O)C(C)=C

InChI

InChIKey=DKEANOQWICTXTP-KBPBESRZSA-N
InChI=1S/C15H16O5/c1-8(2)13(17)14(18)12-10(19-3)6-4-9-5-7-11(16)20-15(9)12/h4-7,13-14,17-18H,1H2,2-3H3/t13-,14-/m0/s1

HIDE SMILES / InChI

Description

Minumicrolin and murrangatin are the diastereomeric isomers. They are 8-substituted 7-methoxycoumarins isolated from Murraya species. They were found to significantly inhibit EBV-EA activation, and preserved the high viability of Raji cells, suggesting that they might be valuable anti-tumor-promoting agents. Minumicrolin showed mild butyrylcholinesterase inhibition activity. It exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
380.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Minumicrolin exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100 with IC(50)=2.9 ug/ml.