Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H5N5O3 |
| Molecular Weight | 147.0928 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(N=O)C(=N)N[N+]([O-])=O
InChI
InChIKey=VZUNGTLZRAYYDE-UHFFFAOYSA-N
InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| PP2A-B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks. | 2015-05-04 |
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| Evaluation of cytogenetic and DNA damage in human lymphocytes treated with adrenaline in vitro. | 2015-02 |
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| miR-21 regulates N-methyl-N-nitro-N'-nitrosoguanidine-induced gastric tumorigenesis by targeting FASLG and BTG2. | 2014-08-04 |
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| The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response. | 2014-07 |
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| Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. | 2012-01 |
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| ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers. | 2011-12-15 |
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| Sex-associated difference in estrogen receptor β expression in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancers in rats. | 2011-10 |
|
| Validation of a genotoxicity test based on p53R2 gene expression in human lymphoblastoid cells. | 2011-09-18 |
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| Quantitative and subcellular localization analysis of the nuclear isoform dUTP pyrophosphatase in alkylating agent-induced cell responses. | 2011-09-05 |
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| α4 is highly expressed in carcinogen-transformed human cells and primary human cancers. | 2011-06-30 |
|
| Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study. | 2011-06 |
|
| Eugenol inhibits cell proliferation via NF-κB suppression in a rat model of gastric carcinogenesis induced by MNNG. | 2011-02 |
|
| N-methyl-N'-nitro-N-nitrosoguanidine induces and cooperates with 12-O-tetradecanoylphorbol-1,3-acetate/sodium butyrate to enhance Epstein-Barr virus reactivation and genome instability in nasopharyngeal carcinoma cells. | 2010-12-05 |
|
| PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. | 2010-07-01 |
|
| Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. | 2010-06-19 |
|
| Comparison of gene expression profiles in BALB/c 3T3 transformed foci exposed to tumor promoting agents. | 2010-03 |
|
| Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. | 2008-11 |
|
| Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. | 2008-06 |
|
| Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells. | 2007-08-01 |
|
| Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. | 2007-02-15 |
|
| Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay. | 2006-12-01 |
|
| Role of O6-methylguanine-DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines. | 2005-11 |
|
| Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline. | 2005-09-01 |
|
| [Cell proliferation inhibitive and apoptosis promoting effects of sanchi extract on GES-1 cell after being transformed by MNNG]. | 2005-08 |
|
| Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis. | 2005-08 |
|
| Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes. | 2005-06 |
|
| N-methyl-N'-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway. | 2005-03-01 |
|
| The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways. | 2005-01-01 |
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| Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. | 2004-12-21 |
|
| Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells. | 2004-08 |
|
| Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers. | 2004-05-18 |
|
| Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations. | 2004-04-01 |
|
| Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture. | 2003-07 |
|
| Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. | 2002-12 |
|
| Cadmium affects genes involved in growth regulation during two-stage transformation of Balb/3T3 cells. | 2002-08-15 |
|
| Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. | 2001-10-09 |
|
| Cell cycle was disturbed in the MNNG-induced initiation stage during in vitro two-stage transformation of Balb/3T3 cells. | 2001-06-21 |
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| Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. | 1999-05-01 |
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| A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. | 1998-06 |
|
| Strain differences in mouse skin tumorigenesis by the promotion of 12-o-tetradecanoylphorbol-13-acetate or benzoyl peroxide. | 1995-05 |
|
| Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride. | 1995-01 |
|
| Dissociation of sensitivities to tumor promotion and progression in outbred and inbred SENCAR mice. | 1992-06-15 |
|
| Expression of human O6-methylguanine-DNA methyltransferase in a DNA excision repair-deficient Chinese hamster ovary cell line and its response to certain alkylating agents. | 1992-01-01 |
|
| Induction of altered hepatocellular foci of hamster for a possible short-term assay for carcinogens. | 1989-03 |
|
| [Promoting effect of bile acids on gastric carcinogenesis induced by MNNG in rats]. | 1989-01 |
|
| Effects of sodium chloride, saccharin, phenobarbital and aspirin on gastric carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine. | 1984-06 |
|
| Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. | 1984-03-01 |
|
| Cocarcinogenic action of aspirin on gastric tumors induced by N-nitroso-N-methylnitroguanidine in rats. | 1983-06 |
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| Code System | Code | Type | Description | ||
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200-730-1
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21759
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5104
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D008769
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300000053709
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m7446
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9369
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6261
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DTXSID2020846
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70-25-7
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12H3O2UGSF
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METHYLNITRONITROSOGUANIDINE
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SUBSTANCE RECORD
