Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H5N5O3 |
| Molecular Weight | 147.0928 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(N=O)C(=N)N[N+]([O-])=O
InChI
InChIKey=VZUNGTLZRAYYDE-UHFFFAOYSA-N
InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)
| Molecular Formula | C2H5N5O3 |
| Molecular Weight | 147.0928 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cocarcinogenic action of aspirin on gastric tumors induced by N-nitroso-N-methylnitroguanidine in rats. | 1983 Jun |
|
| Effects of sodium chloride, saccharin, phenobarbital and aspirin on gastric carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine. | 1984 Jun |
|
| Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. | 1984 Mar 1 |
|
| [Promoting effect of bile acids on gastric carcinogenesis induced by MNNG in rats]. | 1989 Jan |
|
| Induction of altered hepatocellular foci of hamster for a possible short-term assay for carcinogens. | 1989 Mar |
|
| Expression of human O6-methylguanine-DNA methyltransferase in a DNA excision repair-deficient Chinese hamster ovary cell line and its response to certain alkylating agents. | 1992 Jan 1 |
|
| Dissociation of sensitivities to tumor promotion and progression in outbred and inbred SENCAR mice. | 1992 Jun 15 |
|
| Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride. | 1995 Jan |
|
| Strain differences in mouse skin tumorigenesis by the promotion of 12-o-tetradecanoylphorbol-13-acetate or benzoyl peroxide. | 1995 May |
|
| A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. | 1998 Jun |
|
| Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. | 1999 May 1 |
|
| Cell cycle was disturbed in the MNNG-induced initiation stage during in vitro two-stage transformation of Balb/3T3 cells. | 2001 Jun 21 |
|
| Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. | 2001 Oct 9 |
|
| Cadmium affects genes involved in growth regulation during two-stage transformation of Balb/3T3 cells. | 2002 Aug 15 |
|
| Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. | 2002 Dec |
|
| Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture. | 2003 Jul |
|
| Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations. | 2004 Apr 1 |
|
| Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells. | 2004 Aug |
|
| Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. | 2004 Dec 21 |
|
| Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers. | 2004 May 18 |
|
| [Cell proliferation inhibitive and apoptosis promoting effects of sanchi extract on GES-1 cell after being transformed by MNNG]. | 2005 Aug |
|
| Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis. | 2005 Aug |
|
| The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways. | 2005 Jan 1 |
|
| Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes. | 2005 Jun |
|
| N-methyl-N'-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway. | 2005 Mar 1 |
|
| Role of O6-methylguanine-DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines. | 2005 Nov |
|
| Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline. | 2005 Sep 1 |
|
| Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay. | 2006 Dec 1 |
|
| Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells. | 2007 Aug 1 |
|
| Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. | 2007 Feb 15 |
|
| Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. | 2008 Jun |
|
| Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. | 2008 Nov |
|
| N-methyl-N'-nitro-N-nitrosoguanidine induces and cooperates with 12-O-tetradecanoylphorbol-1,3-acetate/sodium butyrate to enhance Epstein-Barr virus reactivation and genome instability in nasopharyngeal carcinoma cells. | 2010 Dec 5 |
|
| PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. | 2010 Jul 1 |
|
| Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. | 2010 Jun 19 |
|
| Comparison of gene expression profiles in BALB/c 3T3 transformed foci exposed to tumor promoting agents. | 2010 Mar |
|
| ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers. | 2011 Dec 15 |
|
| Eugenol inhibits cell proliferation via NF-κB suppression in a rat model of gastric carcinogenesis induced by MNNG. | 2011 Feb |
|
| Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study. | 2011 Jun |
|
| α4 is highly expressed in carcinogen-transformed human cells and primary human cancers. | 2011 Jun 30 |
|
| Sex-associated difference in estrogen receptor β expression in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancers in rats. | 2011 Oct |
|
| Validation of a genotoxicity test based on p53R2 gene expression in human lymphoblastoid cells. | 2011 Sep 18 |
|
| Quantitative and subcellular localization analysis of the nuclear isoform dUTP pyrophosphatase in alkylating agent-induced cell responses. | 2011 Sep 5 |
|
| Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. | 2012 Jan |
|
| miR-21 regulates N-methyl-N-nitro-N'-nitrosoguanidine-induced gastric tumorigenesis by targeting FASLG and BTG2. | 2014 Aug 4 |
|
| The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response. | 2014 Jul |
|
| Evaluation of cytogenetic and DNA damage in human lymphocytes treated with adrenaline in vitro. | 2015 Feb |
|
| PP2A-B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks. | 2015 May 4 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 03:58:58 GMT 2023
by
admin
on
Sat Dec 16 03:58:58 GMT 2023
|
| Record UNII |
12H3O2UGSF
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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12H3O2UGSF
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METHYLNITRONITROSOGUANIDINE
Created by
admin on Sat Dec 16 03:58:59 GMT 2023 , Edited by admin on Sat Dec 16 03:58:59 GMT 2023
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