ZONAMPANEL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H9N5O6.H2O
Molecular Weight	349.2557
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.OC(=O)CN1C(=O)C(=O)NC2=CC(=C(C=C12)N3C=CN=C3)[N+]([O-])=O

InChI

InChIKey=OBHWTRBRRFQGRJ-UHFFFAOYSA-N

InChI=1S/C13H9N5O6.H2O/c19-11(20)5-17-8-4-9(16-2-1-14-6-16)10(18(23)24)3-7(8)15-12(21)13(17)22;/h1-4,6H,5H2,(H,15,21)(H,19,20);1H2

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Description
Sources: https://clinicaltrials.gov/ct2/show/NCT00044057 | https://clinicaltrials.gov/ct2/show/NCT00044070 | Farooqui Akhlaq A., Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases, p. 73, retrieved from:https://books.google.ru/books?id=q_G5aon0WbAC&pg=PA73&redir_esc=y#v=onepage&q&f=false

Zonampanel (also known as YM872) was developed as selective, potent and highly water-soluble competitive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor antagonist. Zonampanel possesses the neuroprotective effect against focal cerebral ischemia and participated in phase II clinical trials in acute stroke patients. However, because of the severe effects, including hallucinations, agitation, and catatonia the further studied were terminated.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effect of AMPA receptor antagonist YM872 on cerebral hematoma size and neurological recovery in the intracerebral hemorrhage rat model.	2003 Apr 25	12706461
Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters.	2004 Oct	15377641
What lies behind serum urate concentration? Insights from genetic and genomic studies.	2009 Dec 29	20090896

Sample Use Guides

In Vivo Use Guide

YM872 (ZONAMPANEL) or placebo will be given as a continuous intravenous (iv) infusion for 24 hours

Route of Administration: Intravenous

Name

Type

Language

ZONAMPANEL

Official Name

English

3,4-Dihydro-7-imidazol-1-yl-6-nitro-2,3-dioxo-1(2H)-quinoxalineacetic acid, monohydrate

Common Name

English

YM872

Code

English

1(2H)-QUINOXALINEACETIC ACID,3,4-DIHYDRO-7-(1H-IMIDAZOL-1-YL)-6-NITRO-2,3-DIOXO-, MONOHYDRATE

Common Name

English

YM 872

Common Name

English

ZONAMPANEL MONOHYDRATE

Common Name

English

YM-872

Code

English

ZONAMPANEL [USAN]

Common Name

English

1(2H)-QUINOXALINEACETIC ACID, 3,4-DIHYDRO-7-(1H-IMIDAZOL-1-YL)-6-NITRO-2,3-DIOXO-, HYDRATE (1:1)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47795