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Details

Stereochemistry ACHIRAL
Molecular Formula C17H23N5O2S
Molecular Weight 361.462
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CPG-52852

SMILES

CCC1=NC2=C(N)N=C3C=CC=CC3=C2N1CCCCNS(C)(=O)=O

InChI

InChIKey=YZOQZEXYFLXNKA-UHFFFAOYSA-N
InChI=1S/C17H23N5O2S/c1-3-14-21-15-16(12-8-4-5-9-13(12)20-17(15)18)22(14)11-7-6-10-19-25(2,23)24/h4-5,8-9,19H,3,6-7,10-11H2,1-2H3,(H2,18,20)

HIDE SMILES / InChI
CPG-52852 (PF-04878691) is a toll-like receptor 7 (TRL7) agonist. The drug was developed by 3M Pharmaceuticals and the Coley Pharmaceutical Group and was investigated in a number of clinical trials in patients with advanced cancer. Sustained tolerability and modest clinical benefit were demonstrated in heavily pretreated recurrent breast, ovarian, and cervix cancers. After Coley was acquired by Pfizer in 2007, the drug was repurposed for the treatment of hepatitis C. A phase 1 clinical trial was conducted. The development of the compound was discontinued because the compound was believed to unlikely to achieve the proof-of-concept criteria as a result of pharmacodynamic modeling.

Approval Year

PubMed

PubMed

TitleDatePubMed
Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers.
2010 Dec
Patents
Name Type Language
CPG-52852
Common Name English
N-(4-(4-AMINO-2-ETHYL-IMIDAZO(4,5-C)QUINOLIN-1-YL)BUTYL)METHANESULFONAMIDE
Systematic Name English
PF-4878691
Code English
852A
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 218105
Created by admin on Fri Dec 15 15:38:18 GMT 2023 , Edited by admin on Fri Dec 15 15:38:18 GMT 2023
FDA ORPHAN DRUG 176603
Created by admin on Fri Dec 15 15:38:18 GMT 2023 , Edited by admin on Fri Dec 15 15:38:18 GMT 2023
Code System Code Type Description
FDA UNII
6PJC3KPK6S
Created by admin on Fri Dec 15 15:38:18 GMT 2023 , Edited by admin on Fri Dec 15 15:38:18 GMT 2023
PRIMARY
NCI_THESAURUS
C61104
Created by admin on Fri Dec 15 15:38:18 GMT 2023 , Edited by admin on Fri Dec 15 15:38:18 GMT 2023
PRIMARY
CAS
532959-63-0
Created by admin on Fri Dec 15 15:38:17 GMT 2023 , Edited by admin on Fri Dec 15 15:38:17 GMT 2023
PRIMARY
SMS_ID
300000042572
Created by admin on Fri Dec 15 15:38:18 GMT 2023 , Edited by admin on Fri Dec 15 15:38:18 GMT 2023
PRIMARY
PUBCHEM
10309114
Created by admin on Fri Dec 15 15:38:18 GMT 2023 , Edited by admin on Fri Dec 15 15:38:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID20201416
Created by admin on Fri Dec 15 15:38:18 GMT 2023 , Edited by admin on Fri Dec 15 15:38:18 GMT 2023
PRIMARY
DRUG BANK
DB12476
Created by admin on Fri Dec 15 15:38:18 GMT 2023 , Edited by admin on Fri Dec 15 15:38:18 GMT 2023
PRIMARY