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Details

Stereochemistry ACHIRAL
Molecular Formula C16H16N4.2ClH
Molecular Weight 337.247
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of STILBAMIDINE DIHYDROCHLORIDE

SMILES

Cl.Cl.NC(=N)C1=CC=C(C=C1)\C=C\C2=CC=C(C=C2)C(N)=N

InChI

InChIKey=BJYYRSDXFXLJIV-SEPHDYHBSA-N
InChI=1S/C16H16N4.2ClH/c17-15(18)13-7-3-11(4-8-13)1-2-12-5-9-14(10-6-12)16(19)20;;/h1-10H,(H3,17,18)(H3,19,20);2*1H/b2-1+;;

HIDE SMILES / InChI
Stilbamidine Isethionate is a salt of Stilbenedicarboxamidine and Hydroxyethanesulfonic acid produced by The Wm. S. Merrell Company and was tested clinically for the treatment of tropical trypano- somiasis and leishmaniasis. It was also reportedly used for tic douloureux. This drug was replaced by Hydroxystilbamidinr isethionate ampuls (Merrell) because this derivative is less toxic and is equally effective in the treatment of the systemic fungus infections, blastomycosis, leishmaniasis, and Indian kala-azar

Originator

Sources: Sueddeutsche Apotheker-Zeitung (1941), 81, 443-4.

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
40 μg/mL
8 mg single, oral
dose: 8 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STILBAMIDINE serum
Mus musculus
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
15 μg × h/mL
8 mg single, oral
dose: 8 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STILBAMIDINE serum
Mus musculus
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
45 min
8 mg single, oral
dose: 8 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
STILBAMIDINE serum
Mus musculus
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
PubMed

PubMed

TitleDatePubMed
The Effect of Quinine and Stilbamidine (M&B 744) on the Reticulo-Endothelial System as Measured by the Congo-Red Index.
1944 Mar
Patents

Patents

Name Type Language
STILBAMIDINE DIHYDROCHLORIDE
Systematic Name English
4,4'-STILBENEDICARBOXAMIDINE, DIHYDROCHLORIDE
Common Name English
4,4'-STILBENEDICARBOXAMIDINE,DIHYDROCHLORIDE
Common Name English
NSC-35605
Code English
BENZENECARBOXIMIDAMIDE, 4,4'-(1,2-ETHENEDIYL)BIS-, HYDROCHLORIDE (1:2)
Systematic Name English
Code System Code Type Description
PUBCHEM
6367036
Created by admin on Sat Dec 16 08:24:57 GMT 2023 , Edited by admin on Sat Dec 16 08:24:57 GMT 2023
PRIMARY
FDA UNII
102Z61E52U
Created by admin on Sat Dec 16 08:24:57 GMT 2023 , Edited by admin on Sat Dec 16 08:24:57 GMT 2023
PRIMARY
NSC
35605
Created by admin on Sat Dec 16 08:24:57 GMT 2023 , Edited by admin on Sat Dec 16 08:24:57 GMT 2023
PRIMARY
CAS
6935-63-3
Created by admin on Sat Dec 16 08:24:57 GMT 2023 , Edited by admin on Sat Dec 16 08:24:57 GMT 2023
PRIMARY