Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H16N4.2ClH |
| Molecular Weight | 337.247 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NC(=N)C1=CC=C(C=C1)\C=C\C2=CC=C(C=C2)C(N)=N
InChI
InChIKey=BJYYRSDXFXLJIV-SEPHDYHBSA-N
InChI=1S/C16H16N4.2ClH/c17-15(18)13-7-3-11(4-8-13)1-2-12-5-9-14(10-6-12)16(19)20;;/h1-10H,(H3,17,18)(H3,19,20);2*1H/b2-1+;;
Stilbamidine Isethionate is a salt of Stilbenedicarboxamidine and Hydroxyethanesulfonic acid produced by The Wm. S. Merrell Company and was tested clinically for the treatment of tropical trypano- somiasis and leishmaniasis. It was also reportedly used for tic douloureux. This drug was replaced by Hydroxystilbamidinr isethionate ampuls (Merrell) because this derivative is less toxic and is equally effective in the treatment of the systemic fungus infections, blastomycosis, leishmaniasis, and Indian kala-azar
Originator
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
40 μg/mL |
8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered: |
STILBAMIDINE serum | Mus musculus population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
15 μg × h/mL |
8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered: |
STILBAMIDINE serum | Mus musculus population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
45 min |
8 mg single, oral dose: 8 mg route of administration: Oral experiment type: SINGLE co-administered: |
STILBAMIDINE serum | Mus musculus population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
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6367036
Created by
admin on Sat Dec 16 08:24:57 GMT 2023 , Edited by admin on Sat Dec 16 08:24:57 GMT 2023
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102Z61E52U
Created by
admin on Sat Dec 16 08:24:57 GMT 2023 , Edited by admin on Sat Dec 16 08:24:57 GMT 2023
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35605
Created by
admin on Sat Dec 16 08:24:57 GMT 2023 , Edited by admin on Sat Dec 16 08:24:57 GMT 2023
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6935-63-3
Created by
admin on Sat Dec 16 08:24:57 GMT 2023 , Edited by admin on Sat Dec 16 08:24:57 GMT 2023
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PRIMARY |
SUBSTANCE RECORD
