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Details

Stereochemistry ACHIRAL
Molecular Formula C16H16N4.2ClH
Molecular Weight 337.247
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of STILBAMIDINE DIHYDROCHLORIDE

SMILES

Cl.Cl.NC(=N)C1=CC=C(C=C1)\C=C\C2=CC=C(C=C2)C(N)=N

InChI

InChIKey=BJYYRSDXFXLJIV-SEPHDYHBSA-N
InChI=1S/C16H16N4.2ClH/c17-15(18)13-7-3-11(4-8-13)1-2-12-5-9-14(10-6-12)16(19)20;;/h1-10H,(H3,17,18)(H3,19,20);2*1H/b2-1+;;

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
MOL RATIO 2 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C16H16N4
Molecular Weight 264.325
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Stilbamidine Isethionate is a salt of Stilbenedicarboxamidine and Hydroxyethanesulfonic acid produced by The Wm. S. Merrell Company and was tested clinically for the treatment of tropical trypano- somiasis and leishmaniasis. It was also reportedly used for tic douloureux. This drug was replaced by Hydroxystilbamidinr isethionate ampuls (Merrell) because this derivative is less toxic and is equally effective in the treatment of the systemic fungus infections, blastomycosis, leishmaniasis, and Indian kala-azar

Originator

Approval Year

Cmax

ValueDoseCo-administeredAnalytePopulation
40 μg/mL
8 mg single, oral
STILBAMIDINE serum
Mus musculus

AUC

ValueDoseCo-administeredAnalytePopulation
15 μg × h/mL
8 mg single, oral
STILBAMIDINE serum
Mus musculus

T1/2

ValueDoseCo-administeredAnalytePopulation
45 min
8 mg single, oral
STILBAMIDINE serum
Mus musculus

Sourcing

PubMed

Patents

Substance Class Chemical
Record UNII
102Z61E52U
Record Status Validated (UNII)
Record Version