Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C8H17N3O2S |
| Molecular Weight | 219.304 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=N)NCCSCC[C@H](N)C(O)=O
InChI
InChIKey=MOLOJNHYNHBPCW-ZETCQYMHSA-N
InChI=1S/C8H17N3O2S/c1-6(9)11-3-5-14-4-2-7(10)8(12)13/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13)/t7-/m0/s1
GW 274150 was developed by GlaxoSmithKline as a selective inhibitor of inducible nitric oxide synthase (iNOS; also known as NOS2). Nitric oxide synthase (NOS) is an important chemical involved in the production of NO. Reduction of NOS, and therefore NO, may be an effective technique for the treatment of migraine headache. GW 274150 offered the potential of anti-inflammatory activity in migraine through a novel mechanism of action. The drug has completed phase II of the clinical trials for patients with rheumatoid arthritis and migraine disorders. In addition, GW 274150 was involved in phase I clinical trial for patients with mild asthma. However, all these studied were discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock. | 2006-02 |
|
| NOS-II is involved in early differentiation of murine cortical, retinal and ES cell-derived neurons-an immunocytochemical and functional approach. | 2002-04 |
|
| Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. | 2000-03-20 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
210354-22-6
Created by
admin on Mon Mar 31 21:16:52 GMT 2025 , Edited by admin on Mon Mar 31 21:16:52 GMT 2025
|
PRIMARY | |||
|
DB12237
Created by
admin on Mon Mar 31 21:16:52 GMT 2025 , Edited by admin on Mon Mar 31 21:16:52 GMT 2025
|
PRIMARY | |||
|
300000042503
Created by
admin on Mon Mar 31 21:16:52 GMT 2025 , Edited by admin on Mon Mar 31 21:16:52 GMT 2025
|
PRIMARY | |||
|
9797017
Created by
admin on Mon Mar 31 21:16:52 GMT 2025 , Edited by admin on Mon Mar 31 21:16:52 GMT 2025
|
PRIMARY | |||
|
0ZZF1V8G63
Created by
admin on Mon Mar 31 21:16:52 GMT 2025 , Edited by admin on Mon Mar 31 21:16:52 GMT 2025
|
PRIMARY |
SUBSTANCE RECORD
