GW-274150

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H17N3O2S
Molecular Weight	219.304
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=N)NCCSCC[C@H](N)C(O)=O

InChI

InChIKey=MOLOJNHYNHBPCW-ZETCQYMHSA-N

InChI=1S/C8H17N3O2S/c1-6(9)11-3-5-14-4-2-7(10)8(12)13/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13)/t7-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C8H17N3O2S
Molecular Weight	219.304
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.annualreports.com/HostedData/AnnualReportArchive/g/LSE_GSK_2004.pdf | https://clinicaltrials.gov/ct2/show/NCT00319137 | https://clinicaltrials.gov/ct2/show/NCT00370435 | https://adisinsight.springer.com/drugs/800018244

GW 274150 was developed by GlaxoSmithKline as a selective inhibitor of inducible nitric oxide synthase (iNOS; also known as NOS2). Nitric oxide synthase (NOS) is an important chemical involved in the production of NO. Reduction of NOS, and therefore NO, may be an effective technique for the treatment of migraine headache. GW 274150 offered the potential of anti-inflammatory activity in migraine through a novel mechanism of action. The drug has completed phase II of the clinical trials for patients with rheumatoid arthritis and migraine disorders. In addition, GW 274150 was involved in phase I clinical trial for patients with mild asthma. However, all these studied were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock.	2006 Feb	16424707

Patents

Sample Use Guides

In Vivo Use Guide

90mg GW274150 will be safe and well-tolerated in this adult and elderly RA patient population on methotrexate

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 03:08:06 GMT 2023` Edited by `admin` on `Sat Dec 16 03:08:06 GMT 2023`
Record UNII	0ZZF1V8G63
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GW-274150

Common Name

English

L-HOMOCYSTEINE, S-(2-((1-IMINOETHYL)AMINO)ETHYL)-

Systematic Name

English

GW274150

Code

English

Code System Code Type Description

CAS

210354-22-6