Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H26N2O3.ClH |
| Molecular Weight | 390.904 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.[H][C@@]12CC[C@H](O)[C@H](C(=O)OC)[C@@]1([H])C[C@@]3([H])N(CCC4=C3NC5=C4C=CC=C5)C2
InChI
InChIKey=PIPZGJSEDRMUAW-JFGPFAEFSA-N
InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17+,18-,19+;/m0./s1
Pseudoyohimbine is an alkaloid isolated from roots of Rauwolfia canescens and in trace amount from Uncaria attenuata. Also, it was found in the leaves, stem and bark of Alstonia quaternata and in root bark of Cabucala striolata and Catharanthus trichophyllus. Pseudoyohimbine is inactive in the periphery as well as in the central nervous system as an antagonist of a1- or a2-adrenoceptors.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Certain pharmacological properties of pseudoyohimbine]. | 1955 Jun |
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| Stereoselective total syntheses of (plus minus)-yohimbine, (plus minus)-psi-yohimbine, and (plus minus)- -yohimbine. | 1972 Jul 12 |
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| Antagonist/agonist-preferring alpha-adrenoceptors or alpha 1/alpha 2-adrenoceptors? | 1980 May 2 |
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| Functional characterization of central alpha-adrenoceptors by yohimbine diastereomers. | 1981 Mar 5 |
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| Inhibition by yohimbine of the calcium-dependent evoked release of [3H]GABA in rat and mouse brain slices in vitro. | 1985 Apr 23 |
Patents
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6363-59-3
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72710638
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0Z94VRU2GA
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m9301
Created by
admin on Sat Dec 16 10:07:20 GMT 2023 , Edited by admin on Sat Dec 16 10:07:20 GMT 2023
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PRIMARY | Merck Index |
SUBSTANCE RECORD
