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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H26N2O3.ClH
Molecular Weight 390.904
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PSEUDOYOHIMBINE HYDROCHLORIDE

SMILES

Cl.COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCC4=C(NC5=C4C=CC=C5)[C@H]3C[C@H]12

InChI

InChIKey=PIPZGJSEDRMUAW-JFGPFAEFSA-N
InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17+,18-,19+;/m0./s1

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C21H26N2O3
Molecular Weight 354.4427
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Pseudoyohimbine is an alkaloid isolated from the bark of Corynanthe johimbe and Rauwolfia canescens.

Originator

Karrer, P.|Salomon, H.
2
Sources: DOI: 10.1002/hlca.192600901139

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
 2.5 µM [Ki]
Antagonist
2849
 1.9 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Inhibition by yohimbine of the calcium-dependent evoked release of [3H]GABA in rat and mouse brain slices in vitro.
1985-04-23
Functional characterization of central alpha-adrenoceptors by yohimbine diastereomers.
1981-03-05
Antagonist/agonist-preferring alpha-adrenoceptors or alpha 1/alpha 2-adrenoceptors?
1980-05-02
Stereoselective total syntheses of (plus minus)-yohimbine, (plus minus)-psi-yohimbine, and (plus minus)- -yohimbine.
1972-07-12
[Certain pharmacological properties of pseudoyohimbine].
1955-06
Patents

Patents

20070212429
2
20080152732
2
20080255101
3

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Pseudoyohimbine, in concentrations up to 10 uM, did not affect the stimulation-evoked release of [3H]GABA in rat and mouse brain slices in vitro.
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:03:23 GMT 2025
Edited
by admin
on Mon Mar 31 23:03:23 GMT 2025
Record UNII
0Z94VRU2GA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PSEUDOYOHIMBINE HYDROCHLORIDE
MI  
Common Name English
3-EPIYOHIMBINE HYDROCHLORIDE
Preferred Name English
PSEUDOYOHIMBINE HYDROCHLORIDE [MI]
Common Name English
YOHIMBAN-16-CARBOXYLIC ACID, 17-HYDROXY-, METHYL ESTER, MONOHYDROCHLORIDE, (3.BETA.,16.ALPHA.,17.ALPHA.)-
Common Name English
Code System Code Type Description
CAS
6363-59-3
Created by admin on Mon Mar 31 23:03:23 GMT 2025 , Edited by admin on Mon Mar 31 23:03:23 GMT 2025
PRIMARY
PUBCHEM
72710638
Created by admin on Mon Mar 31 23:03:23 GMT 2025 , Edited by admin on Mon Mar 31 23:03:23 GMT 2025
PRIMARY
FDA UNII
0Z94VRU2GA
Created by admin on Mon Mar 31 23:03:23 GMT 2025 , Edited by admin on Mon Mar 31 23:03:23 GMT 2025
PRIMARY
MERCK INDEX
m9301
Created by admin on Mon Mar 31 23:03:23 GMT 2025 , Edited by admin on Mon Mar 31 23:03:23 GMT 2025
PRIMARY Merck Index
NIH
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