ISOQUERCITRIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H20O12
Molecular Weight	464.3763
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(O[C@@H](OC2=C(OC3=C(C2=O)C(O)=CC(O)=C3)C4=CC=C(O)C(O)=C4)[C@H](O)[C@H]1O)[C@H](O)CO

InChI

InChIKey=OPJZLUXFQFQYAI-GNPVFZCLSA-N

InChI=1S/C21H20O12/c22-6-12(27)19-16(29)17(30)21(32-19)33-20-15(28)14-11(26)4-8(23)5-13(14)31-18(20)7-1-2-9(24)10(25)3-7/h1-5,12,16-17,19,21-27,29-30H,6H2/t12-,16-,17-,19-,21+/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
Wnt signaling pathway 13 Target ID: GO:0016055 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25359775	Inhibitor 8297
Aldose reductase 44 Target ID: CHEMBL1900 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22261024	Inhibitor 8297	4.5 µM [IC50]
Arginase 1 Target ID: CHEMBL3108635 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24521209	Inhibitor 8297	2.0 µM [IC50]
Carbonic anhydrase VII 34 Target ID: CHEMBL2326 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26498393	Inhibitor 8297	3.8 nM [IC50]

PubMed

Title	Date	PubMed
Inhibition of HIV infection by flavanoids.	1993 Oct	8279812
Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase.	1995 Apr	7541317
A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes.	1999 Jan	10075118
[Chemical constituents from the leaves of crataegus pinnatifida Bge. var. major N.E.Br].	2001 Oct	12579975
The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation.	2003	14992543
Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical.	2003	13678241
[HPLC investigation of antioxidant components in Solidago herba].	2004	16316050
Depsides from the petals of Papaver rhoeas.	2004 Apr	15095160
Glycosides from Grewia damine and Filicium decipiens.	2004 Dec	15595608
Characterization of flavonols in cranberry (Vaccinium macrocarpon) powder.	2004 Jan 28	14733493
[Studies on chemical constituents from Salvia roborowskii Maxim].	2005 Feb	15981878
[Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts].	2005 Jan	15881366
[Studies on chemical constituents from flowers of Apocynum venetum].	2005 Sep	16323543
Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry.	2006	16921563
Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort.	2006 Jan 16	16271822
An unusual C6-C6" linked flavonoid from Miconia cabucu (Melastomataceae).	2007 Jul	17540417
The anti-thrombotic active constituents from Centella asiatica.	2007 May	17473438
Three new 3-benzylbenzofuran-2-one derivatives from Homalium brachybotrys (Flacourtiaceae/Salicaceae s. l.).	2007 Nov	17987500
[Isolation and preparation of flavones from the leaves of Lindera aggregata using high speed counter-current chromatography].	2007 Sep	18161329
[Chemical constituents from Polygonum capitatum and their antioxidation activities in vitro].	2008 Jul	18973013
Soil quality effects on Chenopodium album flavonoid content and antioxidant potential.	2008 Jul 9	18553886
Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by Fluorescence in situ hybridization (FISH).	2008 Mar 26	18303842
Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.).	2008 May-Jun	18669020
Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells.	2008 Oct	18715546
Deep supercooling xylem parenchyma cells of katsura tree (Cercidiphyllum japonicum) contain flavonol glycosides exhibiting high anti-ice nucleation activity.	2008 Sep	18518920
[Chemical study on ethyl acetate soluble portion of Kadsura oblongifolia].	2009 Apr	19623983
[Chemical constituents in Buddleja albiflora].	2009 Dec	20222420
[Flavonoid constituents from herbs of Sarcopyramis bodinieri var. delicata].	2009 Jan	19385178
[Chemical constituents of Galium verum].	2009 Nov	20209910
Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats.	2010 Feb	20033131
[Glycosides from Periploca forrestii].	2010 Mar	20506822
Preparative isolation and purification of four flavonoids from the petals of Nelumbo nucifera by high-speed counter-current chromatography.	2010 May-Jun	20020439
Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats.	2013 Mar 8	23318833

Patents

Name

Type

Language

ISOQUERCITRIN

Official Name

English

QUERCETIN 3-O-.BETA.-D-GLUCOFURANOSIDE

Common Name

English

FEMA NO. 4225

Code

English

ISOQUERCITRIN [INCI]

Common Name

English

FLAVONE, 3,3',4',5,7-PENTAHYDROXY-, 3-.BETA.-D-GLUCOFURANOSIDE

Common Name

English

QUERCETIN 3-(.BETA.-D-GLUCOFURANOSIDE)

Common Name

English

ISOTRIFOLIN

Common Name

English

ISOQUERCITROSIDE

Common Name

English

ISOQUERCETIN ENZYMATICALLY MODIFIED [FHFI]

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIHYDROXYPHENYL)-3-(.BETA.-D-GLUCOFURANOSYLOXY)-5,7-DIHYDROXY-

Common Name

English

ISOTRIFOLIIN

Common Name

English

Classification Tree Code System Code

DSLD

3889 (Number of products:4)