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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H20O12
Molecular Weight 464.3763
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOQUERCITRIN

SMILES

OC[C@@H](O)[C@H]1O[C@@H](OC2=C(OC3=C(C2=O)C(O)=CC(O)=C3)C4=CC(O)=C(O)C=C4)[C@H](O)[C@H]1O

InChI

InChIKey=OPJZLUXFQFQYAI-GNPVFZCLSA-N
InChI=1S/C21H20O12/c22-6-12(27)19-16(29)17(30)21(32-19)33-20-15(28)14-11(26)4-8(23)5-13(14)31-18(20)7-1-2-9(24)10(25)3-7/h1-5,12,16-17,19,21-27,29-30H,6H2/t12-,16-,17-,19-,21+/m1/s1

HIDE SMILES / InChI

Molecular Formula C21H20O12
Molecular Weight 464.3763
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
4.5 µM [IC50]
2.0 µM [IC50]
3.8 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats.
2013-03-08
Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of β-hematin formation.
2011-12-15
Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats.
2011-04-28
Phenolic compounds in leaves of Alchornea triplinervia: anatomical localization, mutagenicity, and antibacterial activity.
2010-08
[Flavonoids of Lysimachia paridiformis var. stenophylla].
2010-07
[Flavonoids and phenolic acid derivatives from flos farfarae].
2010-05
[Glycosides from Periploca forrestii].
2010-03
Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by beta-naphthoflavone.
2010-02-09
Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats.
2010-02
Who is the king? The alpha-hydroxy-beta-oxo-alpha,beta-enone moiety or the catechol B ring: relationship between the structure of quercetin derivatives and their pro-oxidative abilities.
2010-01
Preparative isolation and purification of four flavonoids from the petals of Nelumbo nucifera by high-speed counter-current chromatography.
2009-12-19
[Chemical constituents in Buddleja albiflora].
2009-12
[Chemical constituents of Galium verum].
2009-11
Nondigestible saccharides suppress the bacterial degradation of quercetin aglycone in the large intestine and enhance the bioavailability of quercetin glucoside in rats.
2009-10-28
[Chemical constituents from leaves of Sterculia foetida].
2009-10
[Flavones from Helichrysi flos syn].
2009-06
[Chemical constituents from Neo-Taraxacum siphonathum].
2009-04
[Chemical study on ethyl acetate soluble portion of Kadsura oblongifolia].
2009-04
[Study on chemical constituents of Herba Cirsii].
2009-01
[Flavonoid constituents from herbs of Sarcopyramis bodinieri var. delicata].
2009-01
Chemical composition of the stem bark and leaves of Ficus pandurata Hance.
2009
Phytochemicals of apple peels: isolation, structure elucidation, and their antiproliferative and antioxidant activities.
2008-11-12
[Flavones from flowers of Paulownia fortunei].
2008-11
Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells.
2008-10
Light filtering by epidermal flavonoids during the resistant response of cotton to Xanthomonas protects leaf tissue from light-dependent phytoalexin toxicity.
2008-09
Deep supercooling xylem parenchyma cells of katsura tree (Cercidiphyllum japonicum) contain flavonol glycosides exhibiting high anti-ice nucleation activity.
2008-09
Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.).
2008-08-02
Soil quality effects on Chenopodium album flavonoid content and antioxidant potential.
2008-07-09
[Chemical constituents from Polygonum capitatum and their antioxidation activities in vitro].
2008-07
Determination of quercetin and its glucosides in onion by electrochemical methods.
2008-06-09
Determination of the relative contribution of quercetin and its glucosides to the antioxidant capacity of onion by cyclic voltammetry and spectrophotometric methods.
2008-05-28
Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout.
2008-05-22
Camellia japonica suppresses immunoglobulin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells.
2008-05
[Study on antioxidant activity of constituents from mulberry leaf].
2008-04
Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by Fluorescence in situ hybridization (FISH).
2008-03-26
[Studies on chemical constituents of Arachniodes rhomboidea].
2008-03
Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis.
2008-01-25
[Studies on chemical constituents of Primula sikkmensis].
2008-01
Three new 3-benzylbenzofuran-2-one derivatives from Homalium brachybotrys (Flacourtiaceae/Salicaceae s. l.).
2007-11
[Isolation and preparation of flavones from the leaves of Lindera aggregata using high speed counter-current chromatography].
2007-09
[Studies on antiproliferative effect of flavones compounds isolated from Yao herb medicines].
2007-08
An unusual C6-C6" linked flavonoid from Miconia cabucu (Melastomataceae).
2007-07
The anti-thrombotic active constituents from Centella asiatica.
2007-05
Simultaneous determination of seven flavonoids in Potentilla multifida by HPLC.
2007-04
Development of an HPLC-PAD-MS assay for the identification and quantification of major phenolic edelweiss (Leontopodium alpium Cass.) constituents.
2006-10-06
Constituents from the leaves of Phellodendron amurense and their antioxidant activity.
2006-09
Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry.
2006
[Study on chemical constituents of Lagotis yunnanensis].
2005-09
Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase.
1995-04
Inhibition of HIV infection by flavanoids.
1993-10
Patents

Patents

Substance Class Chemical
Created
by admin
on Mon Mar 31 19:52:33 GMT 2025
Edited
by admin
on Mon Mar 31 19:52:33 GMT 2025
Record UNII
0YX10VRV6J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FEMA NO. 4225
Preferred Name English
ISOQUERCITRIN
INCI  
INCI  
Official Name English
QUERCETIN 3-O-.BETA.-D-GLUCOFURANOSIDE
Common Name English
FLAVONE, 3,3',4',5,7-PENTAHYDROXY-, 3-.BETA.-D-GLUCOFURANOSIDE
Common Name English
QUERCETIN 3-(.BETA.-D-GLUCOFURANOSIDE)
Common Name English
ISOTRIFOLIN
Common Name English
ISOQUERCITROSIDE
Common Name English
ISOQUERCETIN ENZYMATICALLY MODIFIED [FHFI]
Common Name English
4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIHYDROXYPHENYL)-3-(.BETA.-D-GLUCOFURANOSYLOXY)-5,7-DIHYDROXY-
Common Name English
ISOTRIFOLIIN
Common Name English
Classification Tree Code System Code
DSLD 3889 (Number of products:4)
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
NCI_THESAURUS C270
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
Code System Code Type Description
MESH
C016527
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
CHEBI
28299
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
WIKIPEDIA
Isoquercitrin
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
EPA CompTox
DTXSID80904976
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
CAS
21637-25-2
Created by admin on Mon Mar 31 19:52:33 GMT 2025 , Edited by admin on Mon Mar 31 19:52:33 GMT 2025
PRIMARY
NCI_THESAURUS
C99879
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
PUBCHEM
5484006
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
FDA UNII
0YX10VRV6J
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
ECHA (EC/EINECS)
244-488-5
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
CHEBI
68352
Created by admin on Mon Mar 31 19:52:34 GMT 2025 , Edited by admin on Mon Mar 31 19:52:34 GMT 2025
PRIMARY
Related Record Type Details
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