U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H20O12
Molecular Weight 464.3763
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOQUERCITRIN

SMILES

[H][C@@]1(O[C@@H](OC2=C(OC3=C(C2=O)C(O)=CC(O)=C3)C4=CC=C(O)C(O)=C4)[C@H](O)[C@H]1O)[C@H](O)CO

InChI

InChIKey=OPJZLUXFQFQYAI-GNPVFZCLSA-N
InChI=1S/C21H20O12/c22-6-12(27)19-16(29)17(30)21(32-19)33-20-15(28)14-11(26)4-8(23)5-13(14)31-18(20)7-1-2-9(24)10(25)3-7/h1-5,12,16-17,19,21-27,29-30H,6H2/t12-,16-,17-,19-,21+/m1/s1

HIDE SMILES / InChI

Molecular Formula C21H20O12
Molecular Weight 464.3763
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
4.5 µM [IC50]
2.0 µM [IC50]
3.8 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase.
1995 Apr
[Chemical constituents from the leaves of crataegus pinnatifida Bge. var. major N.E.Br].
2001 Oct
[HPLC investigation of antioxidant components in Solidago herba].
2004
[Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts].
2005 Jan
[Study on chemical constituents of Lagotis yunnanensis].
2005 Sep
Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort.
2006 Jan 16
[Isolation and preparation of flavones from the leaves of Lindera aggregata using high speed counter-current chromatography].
2007 Sep
Camellia japonica suppresses immunoglobulin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells.
2008 May
[Flavones from flowers of Paulownia fortunei].
2008 Nov
Phytochemicals of apple peels: isolation, structure elucidation, and their antiproliferative and antioxidant activities.
2008 Nov 12
Chemical composition of the stem bark and leaves of Ficus pandurata Hance.
2009
Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by beta-naphthoflavone.
2010 Feb 9
Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats.
2011 Apr 28
Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of β-hematin formation.
2011 Dec 15
Patents

Patents

Substance Class Chemical
Created
by admin
on Thu Jul 06 02:42:51 UTC 2023
Edited
by admin
on Thu Jul 06 02:42:51 UTC 2023
Record UNII
0YX10VRV6J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ISOQUERCITRIN
INCI  
INCI  
Official Name English
QUERCETIN 3-O-.BETA.-D-GLUCOFURANOSIDE
Common Name English
FEMA NO. 4225
Code English
ISOQUERCITRIN [INCI]
Common Name English
FLAVONE, 3,3',4',5,7-PENTAHYDROXY-, 3-.BETA.-D-GLUCOFURANOSIDE
Common Name English
QUERCETIN 3-(.BETA.-D-GLUCOFURANOSIDE)
Common Name English
ISOTRIFOLIN
Common Name English
ISOQUERCITROSIDE
Common Name English
ISOQUERCETIN ENZYMATICALLY MODIFIED [FHFI]
Common Name English
4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIHYDROXYPHENYL)-3-(.BETA.-D-GLUCOFURANOSYLOXY)-5,7-DIHYDROXY-
Common Name English
ISOTRIFOLIIN
Common Name English
Classification Tree Code System Code
DSLD 3889 (Number of products:4)
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
NCI_THESAURUS C270
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
Code System Code Type Description
MESH
C016527
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
CHEBI
28299
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
WIKIPEDIA
Isoquercitrin
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
EPA CompTox
DTXSID80904976
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
CAS
21637-25-2
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
NCI_THESAURUS
C99879
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
PUBCHEM
5484006
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
FDA UNII
0YX10VRV6J
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
ECHA (EC/EINECS)
244-488-5
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
CHEBI
68352
Created by admin on Thu Jul 06 02:42:51 UTC 2023 , Edited by admin on Thu Jul 06 02:42:51 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
NMT 2%
USP