Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H26N5O8.Gd.3H2O |
Molecular Weight | 627.7 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.O.[Gd+3].CNC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)NC)CC([O-])=O)CC([O-])=O
InChI
InChIKey=WYKPQCVMUQQKCL-UHFFFAOYSA-K
InChI=1S/C16H29N5O8.Gd.3H2O/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;;;;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);;3*1H2/q;+3;;;/p-3
Originator
Sources: http://www.ncbi.nlm.nih.gov/pubmed/?term=1802131
Curator's Comment: Gadodiamide was developed by Salutar (Sunnyvale, Calif).
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Diagnostic | OMNISCAN Approved UseDiagnostic magnetic resonance imaging (MRI) indicated for intravenous use to visualize lesions with abnormal vascularity in the brain, spine, and associated tissues; facilitate the visualization of lesions with abnormal vascularity within the thoracic, abdominal, pelvic cavities, and the retroperitoneal space. Launch Date1993 |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
77.8 min |
0.1 mmol/kg single, intravenous dose: 0.1 mmol/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GADODIAMIDE unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
100% |
0.1 mmol/kg single, intravenous dose: 0.1 mmol/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
GADODIAMIDE unknown | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/201277Orig1s000PharmR.pdf#page=53 Page: 53.0 |
PubMed
Title | Date | PubMed |
---|---|---|
Neurotoxic potential of gadodiamide after injection into the lateral cerebral ventricle of rats. | 1998 Sep |
|
Gadolinium arteriography complicated by acute pancreatitis and acute renal failure. | 2001 Mar |
|
Gadodiamide-associated nephrogenic systemic fibrosis. | 2007 Jun |
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Case-control study of gadodiamide-related nephrogenic systemic fibrosis. | 2007 Nov |
|
Nephrogenic systemic fibrosis: possible association with a predisposing infection. | 2008 Apr |
|
Semi-quantification of endolymphatic size on MR imaging after intravenous injection of single-dose gadodiamide: comparison between two types of processing strategies. | 2013 Dec 25 |
|
IV Administered Gadodiamide Enters the Lumen of the Prostatic Glands: X-Ray Fluorescence Microscopy Examination of a Mouse Model. | 2015 Sep |
|
T1 Signal-Intensity Increase in the Dentate Nucleus after Multiple Exposures to Gadodiamide: Intraindividual Comparison between 2 Commonly Used Sequences. | 2016 Aug |
|
Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide. | 2016 Jul 11 |
|
Investigation of the ototoxicity of gadoteridol (ProHance) and gadodiamide (Omniscan) in mice. | 2016 Nov |
|
Signal intensity change on unenhanced T1-weighted images in dentate nucleus following gadobenate dimeglumine in patients with and without previous multiple administrations of gadodiamide. | 2016 Nov |
Patents
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0RPE15QPL0
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SUB126938
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122795-43-1
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DB00225
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DTXSID9048647
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31642
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76964236
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ACTIVE MOIETY
SUBSTANCE RECORD