U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C17H34O2
Molecular Weight 270.4507
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOPROPYL MYRISTATE

SMILES

CCCCCCCCCCCCCC(=O)OC(C)C

InChI

InChIKey=AXISYYRBXTVTFY-UHFFFAOYSA-N
InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3

HIDE SMILES / InChI

Description

Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent or lubricant in beauty products. Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient. It is most often used as an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Approval Year

2000
172
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments.
2006-11-16
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
2006-06-29
Analysis of the phase diagram and microstructural transitions in phospholipid microemulsion systems using high-resolution ultrasonic spectroscopy.
2006-06-20
Identification of penetration enhancers for testosterone transdermal delivery from spray formulations.
2006-06-12
Effect of the composition of lecithin/n-propanol/isopropyl myristate/water microemulsions on barrier properties of mice skin for transdermal permeation of tetracaine hydrochloride: in vitro.
2006-06-01
Bicontinuous water-AOT/Tween85-isopropyl myristate microemulsion: a new vehicle for transdermal delivery of cyclosporin A.
2006-06
Effect of oil phase lipophilicity on in vitro drug release from o/w microemulsions with low surfactant content.
2006-06
Synthesis and transdermal permeation-enhancing activity of ketone, amide, and alkane analogs of Transkarbam 12.
2006-05-01
Microemulsions as potential ocular drug delivery systems: phase diagrams and physical properties depending on ingredients.
2006-04-06
Enhanced skin permeation of salicylate by ion-pair formation in non-aqueous vehicle and further enhancement by ethanol and l-menthol.
2006-04
Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: in vivo.
2006-03-01
Evaluation of chemical enhancers in the transdermal delivery of lidocaine.
2006-02-03
Enhanced delivery of retinoic acid to skin by cationic liposomes.
2006-02
Effects of solvents on skin permeation of formoterol fumarate.
2006-01
Formulation and physicochemical characterization of microemulsion system using isopropyl myristate, medium-chain glyceride, polysorbate 80 and water.
2005-12
Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin.
2005-11-28
The effect of pH and organic ester penetration enhancers on skin permeation kinetics of terbutaline sulfate from pseudolatex-type transdermal delivery systems through mouse and human cadaver skins.
2005-09-30
The effect of internal structure of selected water-Tween 40-Imwitor 308-IPM microemulsions on ketoprofene release.
2005-09-30
Preparation and in vitro anticancer activity of wheat germ agglutinin (WGA)-conjugated PLGA nanoparticles loaded with paclitaxel and isopropyl myristate.
2005-09-20
Release and permeation kinetics of caffeine from bioadhesive transdermal films.
2005-09-02
Skin permeation of lidocaine from crystal suspended oily formulations.
2005-09
Water solubilization capacity of mixed reverse micelles: effect of surfactant component, the nature of the oil, and electrolyte concentration.
2005-08-01
Effects of ionization and penetration enhancers on the transdermal delivery of 5-fluorouracil through excised human stratum corneum.
2005-07-14
On the incorporation of the non-steroidal anti-inflammatory naproxen into cationic O/W microemulsions.
2005-06-25
Rheological behavior of water-in-oil emulsions stabilized by hydrophobic bentonite particles.
2005-06-07
Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents.
2005-06
IPM/DOSS/water microemulsions as reactors for silver sulfadiazine nanocrystal synthesis.
2005-06
In vitro release of diclofenac diethylamine from caprylocaproyl macrogolglycerides based microemulsions.
2005-05-30
Reactive oxygen species produced upon photoexcitation of sunscreens containing titanium dioxide (an EPR study).
2005-05-13
[Isopropyl myristate molecular gels and drug-loaded transdermal capability].
2005-05
Enhanced in vitro percutaneous absorption and in vivo anti-inflammatory effect of a selective cyclooxygenase inhibitor using microemulsion.
2005-05
Transdermal absorption of propofol in rats.
2005-05
Characterisation of the water-isopropyl myristate system.
2005-04-27
AOT water-in-oil microemulsions as a penetration enhancer in transdermal drug delivery of 5-fluorouracil.
2005-03-10
Novel approach for classifying chemicals according to skin sensitizing potency by non-radioisotopic modification of the local lymph node assay.
2005-03-04
Linker-based bio-compatible microemulsions.
2005-03-01
An attempt to clarify the influence of glycerol, propylene glycol, isopropyl myristate and a combination of propylene glycol and isopropyl myristate on human stratum corneum.
2005-03
Study of sensory properties of emollients used in cosmetics and their correlation with physicochemical properties.
2005-02-28
Permeation study of five formulations of alpha-tocopherol acetate through human cadaver skin.
2005-02-16
Biopharmaceutical considerations on antihistamine effects of topically administered emedastine.
2005-01
Evaluation of skin permeability of sesquiterpenes of an innovative supercritical carbon dioxide Arnica extract by HPLC/DAD/MS.
2005-01
New vehicle based on a microemulsion for topical ocular administration of dexamethasone.
2004-12
Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride.
2004-09-13
Feasibility studies of dermal delivery of paclitaxel with binary combinations of ethanol and isopropyl myristate: role of solubility, partitioning and lipid bilayer perturbation.
2004-09-03
Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG).
2004-09
In vitro permeation studies comparing bovine nasal mucosa, porcine cornea and artificial membrane: androstenedione in microemulsions and their components.
2004-07
Lipid nano/submicron emulsions as vehicles for topical flurbiprofen delivery.
2004-06-18
Topical delivery of a model phenolic drug: alkyloxycarbonyl prodrugs of acetaminophen.
2004-06
Development of a new formulation combining calcipotriol and betamethasone dipropionate in an ointment vehicle.
2004
[Research on components of Cornus officinalis extracted by supercritical carbon dioxide].
2003-12
Patents

Patents

JP1067580A
3
JP2001058960A
2
JP2002087964A
1
JP2002500671A
2
JP2007503516A
3
JP4806162B2
16
JPH02247117A
1
JPH03291218A
7
JPH0413617A
1
JPH0446110A
1
JPH069917A
1
JPH0812374A
1
JPH08133963A
1
JPH08133972A
7
JPH08259403A
1
JPH09110681A
1
JPH09110696A
1
JPH09227375A
1
JPH09263524A
2
JPH10167952A
1
JPS5452734A
2
JPS56110614A
2
JPS594432A
1
JPS60115509A
1
JPS6310710A
1
JPS63227524A
1
JPS6425720A
1
JPS6450816A
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Topical
In Vitro Use Guide
Unknown
Name Type Language
TETRADECONOIC ACID, 1-METHYLETHYL ESTER
Preferred Name English
ISOPROPYL MYRISTATE
EP   FHFI   HSDB   II   INCI   MART.   MI   USAN   USP-RS   VANDF   WHO-DD  
USAN   INCI  
Official Name English
ISOPROPYL MYRISTATE [MI]
Common Name English
ISOPROPYL MYRISTATE [II]
Common Name English
ISOPROPYL TETRADECANOATE
Systematic Name English
FEMA NO. 3556
Code English
Isopropyl myristate [WHO-DD]
Common Name English
ISOPROPYL MYRISTATE [HSDB]
Common Name English
ISOPROPYL MYRISTATE [VANDF]
Common Name English
PROPAN-2-YL TETRADECANOATE
Systematic Name English
Myristic acid, isopropyl alcohol ester
Common Name English
ESTERGEL
Brand Name English
NSC-406280
Code English
ISOPROPYL MYRISTATE [MART.]
Common Name English
ISOPROPYL MYRISTATE [USP-RS]
Common Name English
ISOPROPYL TETRADECANOIC ACID
Systematic Name English
ISOPROPYL MYRISTATE [EP MONOGRAPH]
Common Name English
ISOPROPYL MYRISTATE [USAN]
Common Name English
ISOPROPYL MYRISTATE [FHFI]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION ISOPROPYL MYRISTATE
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
EPA PESTICIDE CODE 207
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
Code System Code Type Description
EVMPD
SUB14281MIG
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
USAN
SS-22
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
ECHA (EC/EINECS)
203-751-4
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
MESH
C008205
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
EPA CompTox
DTXSID0026838
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
PUBCHEM
8042
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
RS_ITEM_NUM
1350400
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
SMS_ID
100000077567
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
CONCEPT Industrial Aid
CAS
110-27-0
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
DRUG BANK
DB13966
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
NCI_THESAURUS
C76717
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
DAILYMED
0RE8K4LNJS
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
RXCUI
27985
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY RxNorm
MERCK INDEX
m6531
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY Merck Index
JECFA MONOGRAPH
61
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
NSC
406280
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
HSDB
626
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
WIKIPEDIA
ISOPROPYL MYRISTATE
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
FDA UNII
0RE8K4LNJS
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
ChEMBL
CHEMBL207602
Created by admin on Mon Mar 31 17:46:28 GMT 2025 , Edited by admin on Mon Mar 31 17:46:28 GMT 2025
PRIMARY
SUBSTANCE RECORD
Structure of ISOPROPYL MYRISTATE
NIH
NCATS
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ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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