IMIRESTAT

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H8F2N2O2
Molecular Weight	286.233
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of IMIRESTAT

Structure Search

SMILES

FC1=CC2=C(C=C1)C3=C(C=C(F)C=C3)C24NC(=O)NC4=O

InChI

InChIKey=QCCHBHSAIQIQGO-UHFFFAOYSA-N

InChI=1S/C15H8F2N2O2/c16-7-1-3-9-10-4-2-8(17)6-12(10)15(11(9)5-7)13(20)18-14(21)19-15/h1-6H,(H2,18,19,20,21)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1495891 | https://www.ncbi.nlm.nih.gov/pubmed/2127314 | https://www.ncbi.nlm.nih.gov/pubmed/2106677

Imirestat is an aldose reductase inhibitor patented by global medical company Alcon Laboratories for the late complications of diabetes.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase inhibition.	1992 Mar 30	1374869
Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: implications for cardiotoxicity of doxorubicin-taxane chemotherapies.	2006 Jul	16614166

Patents

Patents

Sample Use Guides

In Vivo Use Guide

single doses of 20 to 50 mg

Route of Administration: Oral

Name

Type

Language

IMIRESTAT

Official Name

English

AL-1576

Code

English

HOE-843

Code

English

imirestat [INN]

Common Name

English

2,7-DIFLUOROSPIRO(FLUORENE-9,4'-IMIDAZOLIDINE)-2',5'-DIONE

Systematic Name

English

HOE 843

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C72880

Created by admin on Fri Dec 15 15:51:10 GMT 2023 , Edited by admin on Fri Dec 15 15:51:10 GMT 2023

Code System Code Type Description

CAS

89391-50-4

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INN

6286

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NCI_THESAURUS

C96290

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SMS_ID

100000083940

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FDA UNII

0PM69S95UQ

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EPA CompTox

DTXSID80237635

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ChEMBL

CHEMBL269455

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EVMPD

SUB08154MIG

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PUBCHEM

65673

Created by admin on Fri Dec 15 15:51:10 GMT 2023 , Edited by admin on Fri Dec 15 15:51:10 GMT 2023

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ACTIVE MOIETY


					0PM69S95UQ

IMIRESTAT