SARIPIDEM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20ClN3O
Molecular Weight	341.835
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC(=O)N(C)CC1=C(N=C2C=CC=CN12)C3=CC=C(Cl)C=C3

InChI

InChIKey=LIFDPEORUVTOCP-UHFFFAOYSA-N

InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11224318 | https://adisinsight.springer.com/drugs/800001372

Synthélabo developed a saripidem (also known as SL 850274) as a potential anxiolytic agent that modulates the benzodiazepine-binding site on GABAA receptor via primary binding with ω1 subtype. Saripidem was studied in phase II clinical trials for the treatment of patients with anxiety disorders. However, information about the further development of the drug is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue.	1995 Mar	11224318
A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A2.	2015	26196520
Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis.	2017 Apr 21	28362504

Name

Type

Language

SARIPIDEM

Official Name

English

saripidem [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29756